Characterization of the Cancer Spectrum in Men With Germline BRCA1 and BRCA2 Pathogenic Variants

Author:

Silvestri Valentina1,Leslie Goska2,Barnes Daniel R.2,Agnarsson Bjarni A.34,Aittomäki Kristiina5,Alducci Elisa6,Andrulis Irene L.78,Barkardottir Rosa B.39,Barroso Alicia10,Barrowdale Daniel2,Benitez Javier1112,Bonanni Bernardo13,Borg Ake14,Buys Saundra S.15,Caldés Trinidad16,Caligo Maria A.17,Capalbo Carlo1,Campbell Ian18,Chung Wendy K.19,Claes Kathleen B.M.20,Colonna Sarah V.15,Cortesi Laura21,Couch Fergus J.22,de la Hoya Miguel16,Diez Orland2324,Ding Yuan Chun25,Domchek Susan26,Easton Douglas F.227,Ejlertsen Bent28,Engel Christoph29,Evans D. Gareth30,Feliubadalò Lidia31,Foretova Lenka32,Fostira Florentia33,Géczi Lajos34,Gerdes Anne-Marie35,Glendon Gord7,Godwin Andrew K.36,Goldgar David E.37,Hahnen Eric3839,Hogervorst Frans B.L.40,Hopper John L.41,Hulick Peter J.4243,Isaacs Claudine44,Izquierdo Angel45,James Paul A.1846,Janavicius Ramunas47,Jensen Uffe Birk48,John Esther M.49,Joseph Vijai50,Konstantopoulou Irene33,Kurian Allison W.49,Kwong Ava515253,Landucci Elisabetta54,Lesueur Fabienne555657,Loud Jennifer T.58,Machackova Eva32,Mai Phuong L.59,Majidzadeh-A Keivan60,Manoukian Siranoush61,Montagna Marco6,Moserle Lidia6,Mulligan Anna Marie6263,Nathanson Katherine L.26,Nevanlinna Heli64,Ngeow Yuen Ye Joanne6566,Nikitina-Zake Liene67,Offit Kenneth5068,Olah Edith69,Olopade Olufunmilayo I.70,Osorio Ana1012,Papi Laura71,Park Sue K.727374,Pedersen Inge Sokilde75,Perez-Segura Pedro16,Petersen Annabeth H.76,Pinto Pedro77,Porfirio Berardino71,Pujana Miquel Angel78,Radice Paolo79,Rantala Johanna80,Rashid Muhammad U.8182,Rosenzweig Barak8384,Rossing Maria85,Santamariña Marta868788,Schmutzler Rita K.3839,Senter Leigha89,Simard Jacques90,Singer Christian F.91,Solano Angela R.92,Southey Melissa C.939495,Steele Linda25,Steinsnyder Zoe50,Stoppa-Lyonnet Dominique969798,Tan Yen Yen99,Teixeira Manuel R.77100,Teo Soo H.101102,Terry Mary Beth103,Thomassen Mads104,Toland Amanda E.105,Torres-Esquius Sara23,Tung Nadine106,van Asperen Christi J.107,Vega Ana868788,Viel Alessandra108,Vierstraete Jeroen20,Wappenschmidt Barbara3839,Weitzel Jeffrey N.109,Wieme Greet20,Yoon Sook-Yee101,Zorn Kristin K.59,McGuffog Lesley2,Parsons Michael T.110,Hamann Ute81,Greene Mark H.58,Kirk Judy A.111,Neuhausen Susan L.25,Rebbeck Timothy R.112113,Tischkowitz Marc114115,Chenevix-Trench Georgia110,Antoniou Antonis C.2,Friedman Eitan84116,Ottini Laura1,

Affiliation:

1. Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy

2. Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom

3. Department of Pathology, Landspitali University Hospital, Reykjavik, Iceland

4. School of Medicine, University of Iceland, Reykjavik, Iceland

5. Department of Clinical Genetics, Helsinki University Hospital, University of Helsinki, Helsinki, Finland

6. Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV–IRCCS, Padua, Italy

7. Lunenfeld-Tanenbaum Research Institute, Fred A. Litwin Center for Cancer Genetics, Mount Sinai Hospital, Toronto, Ontario, Canada

8. Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada

9. BMC (Biomedical Centre), Faculty of Medicine, University of Iceland, Reykjavik, Iceland

10. Human Genetics Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre, Madrid, Spain

11. Human Genetics Group and Genotyping Unit, CEGEN, Human Cancer Genetics Programme, Spanish National Cancer Research Centre, Madrid, Spain

12. Spanish Network on Rare Diseases (CIBERER), Madrid, Spain

13. Division of Cancer Prevention and Genetics–IEO, European Institute of Oncology IRCCS, Milan, Italy

14. Department of Oncology, Lund University, Skåne University Hospital, Lund, Sweden

15. Huntsman Cancer Institute, Department of Internal Medicine, University of Utah Health, Salt Lake City

16. Instituto de Investigación Sanitaria San Carlos (IdISSC), Centro Investigación Biomédica en Red de Cáncer (CIBERONC), Medical Oncology Department, Hospital Clínico San Carlos, Madrid, Spain

17. Section of Molecular Genetics, Department of Laboratory Medicine, University Hospital of Pisa, Pisa, Italy

18. Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria, Australia

19. Departments of Pediatrics and Medicine, Columbia University, New York, New York

20. Centre for Medical Genetics, Ghent University, Gent, Belgium

21. Department of Oncology and Haematology, University of Modena and Reggio Emilia, Modena, Italy

22. Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota

23. Hereditary Cancer Genetics Group, Vall d’Hebron Institute of Oncology, Barcelona, Spain

24. Area of Clinical and Molecular Genetics, University Hospital of Vall d’Hebron, Barcelona, Spain

25. Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, California

26. Abramson Cancer Center, Perelman School of Medicine, Department of Medicine, University of Pennsylvania, Philadelphia

27. Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, United Kingdom

28. Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

29. Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany

30. Genomic Medicine, Manchester Academic Health Sciences Centre, Division of Evolution and Genomic Science, Manchester University, Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom

31. Molecular Diagnostic Unit, Hereditary Cancer Program, IDIBELL (Bellvitge Biomedical Research Institute), Catalan Institute of Oncology, CIBERONC, Barcelona, Spain

32. Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic

33. Molecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research “Demokritos”, Athens, Greece

34. Medical Oncology Center, National Institute of Oncology, Budapest, Hungary

35. Department of Clinical Genetics, Rigshospitalet, Copenhagen, Denmark

36. Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City

37. Huntsman Cancer Institute, Department of Dermatology, University of Utah School of Medicine, Salt Lake City

38. Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany

39. Center for Hereditary Breast and Ovarian Cancer, University Hospital of Cologne, Cologne, Germany

40. Family Cancer Clinic, Netherlands Cancer Institute, Amsterdam, the Netherlands

41. Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia

42. Center for Medical Genetics, NorthShore University HealthSystem, Evanston, Illinois

43. The University of Chicago Pritzker School of Medicine, Chicago, Illinois

44. Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC

45. Genetic Counseling Unit, Hereditary Cancer Program, IDIBGI (Institut d’Investigació Biomèdica de Girona), Catalan Institute of Oncology, CIBERONC, Girona, Spain

46. Parkville Familial Cancer Centre, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia

47. Hematology, Oncology and Transfusion Medicine Center, Department of Molecular and Regenerative Medicine, Vilnius University Hospital Santariskiu Clinics, Vilnius, Lithuania

48. Department of Clinical Genetics, Aarhus University Hospital, Aarhus, Denmark

49. Department of Epidemiology and Population Health, Division of Oncology, Department of Medicine, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, California

50. Clinical Genetics Research Lab, Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, New York

51. Hong Kong Hereditary Breast Cancer Family Registry, Cancer Genetics Centre, Happy Valley, Hong Kong

52. Department of Surgery, University of Hong Kong, Pok Fu Lam, Hong Kong

53. Department of Surgery and Cancer Genetics Center, Hong Kong Sanatorium and Hospital, Happy Valley, Hong Kong

54. UO Oncologia Medica, Azienda Ospedaliero Universitaria Pisana, Pisa, Italy

55. Genetic Epidemiology of Cancer Team, Inserm, U900, Paris, France

56. Institut Curie, Paris, France

57. Mines ParisTech, Fontainebleau, France

58. Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland

59. Magee-Womens Hospital, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania

60. Breast Cancer Research Center, Genetics Department, Motamed Cancer Institute, ACECR, Tehran, Iran

61. Unit of Medical Genetics, Department of Medical Oncology and Hematology, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy

62. Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada

63. Laboratory Medicine Program, University Health Network, Toronto, Ontario, Canada

64. Department of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland

65. Cancer Genetics Service, National Cancer Centre Singapore, Singapore

66. Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore

67. Latvian Biomedical Research and Study Centre, Riga, Latvia

68. Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York

69. Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary

70. Center for Clinical Cancer Genetics, The University of Chicago, Chicago, Illinois

71. Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy

72. Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea

73. Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, Korea

74. Cancer Research Institute, Seoul National University, Seoul, Korea

75. Molecular Diagnostics, Department of Clinical Medicine, Aalborg University Hospital, Aalborg University, Aalborg, Denmark

76. Department of Clinical Genetics, Vejle Hospital, Vejle, Denmark

77. Department of Genetics, Portuguese Oncology Institute, Porto, Portugal

78. ProCURE, Catalan Institute of Oncology, IDIBELL (Bellvitge Biomedical Research Institute), Barcelona, Spain

79. Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy

80. Clinical Genetics, Karolinska Institutet, Stockholm, Sweden

81. Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany

82. Department of Basic Sciences, Shaukat Khanum Memorial Cancer Hospital and Research Centre (SKMCH & RC), Lahore, Pakistan

83. Male High Risk Clinic, Uro-Oncology Service, Urology Department, Chaim Sheba Medical Center, Tel-Hashomer, Israel

84. Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel

85. Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

86. Fundación Pública Galega Medicina Xenómica-SERGAS, Santiago de Compostela, Spain

87. Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Santiago de Compostela, Spain

88. Centro de Investigación en Red de Enfermedades Raras (CIBERER), Spain

89. Clinical Cancer Genetics Program, The Comprehensive Cancer Center, Division of Human Genetics, Department of Internal Medicine, The Ohio State University, Columbus

90. Genomics Center, Centre Hospitalier Universitaire de Québec–Université Laval, Research Centre, Québec City, Québec, Canada

91. Comprehensive Cancer Center, Department of OB/GYN, Medical University of Vienna, Vienna, Austria

92. INBIOMED, Faculty of Medicine/UBA-CONICET and Genotyping Laboratory, Department of Clinical Chemistry, Centro de Educacion Medica e Investigaciones Clinicas, CABA, Argentina

93. Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia

94. Department of Clinical Pathology, The University of Melbourne, Melbourne, Victoria, Australia

95. Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia

96. Service de Génétique, Institut Curie, Paris, France

97. Department of Tumour Biology, INSERM U830, Paris, France

98. Université de Paris, Paris, France

99. Department of OB/GYN, Medical University of Vienna, Vienna, Austria

100. Biomedical Sciences Institute (ICBAS), University of Porto, Porto, Portugal

101. Cancer Research Malaysia, Subang Jaya, Selangor, Malaysia

102. Breast Cancer Research Unit, Cancer Research Institute, University Malaya Medical Centre, Kuala Lumpur, Malaysia

103. Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York

104. Department of Clinical Genetics, Odense University Hospital, Odense, Denmark

105. Department of Cancer Biology and Genetics, The Ohio State University, Columbus

106. Department of Medical Oncology, Beth Israel Deaconess Medical Center, Boston, Massachusetts

107. Department of Clinical Genetics, Leiden University Medical Center, Leiden, the Netherlands

108. Division of Functional onco-genomics and genetics, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano, Italy

109. Clinical Cancer Genetics, City of Hope, Duarte, California

110. Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia

111. Centre for Cancer Research, University of Sydney at The Westmead Institute for Medical Research, and Familial Cancer Service, Westmead Hospital, New South Wales, Australia

112. Harvard T.H. Chan School of Public Health, Boston, Massachusetts

113. Dana-Farber Cancer Institute, Boston, Massachusetts

114. Program in Cancer Genetics, Departments of Human Genetics and Oncology, McGill University, Montréal, Quebec, Canada

115. Department of Medical Genetics, National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge, Cambridge, United Kingdom

116. The Suzanne Levy-Gertner Oncogenetics Unit, Chaim Sheba Medical Center, Ramat Gan, Israel

Publisher

American Medical Association (AMA)

Subject

Oncology,Cancer Research

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