Association of Cerebral Amyloid-β Aggregation With Cognitive Functioning in Persons Without Dementia

Author:

Jansen Willemijn J.1,Ossenkoppele Rik2345,Tijms Betty M.2,Fagan Anne M.6,Hansson Oskar7,Klunk William E.8,van der Flier Wiesje M.29,Villemagne Victor L.10,Frisoni Giovanni B.1112,Fleisher Adam S.131415,Lleó Alberto16,Mintun Mark A.17,Wallin Anders18,Engelborghs Sebastiaan19,Na Duk L.20,Chételat Gäel21,Molinuevo José Luis22,Landau Susan M.5,Mattsson Niklas7,Kornhuber Johannes23,Sabri Osama24,Rowe Christopher C.610,Parnetti Lucilla25,Popp Julius26,Fladby Tormod27,Jagust William J.5,Aalten Pauline1,Lee Dong Young28,Vandenberghe Rik29,Resende de Oliveira Catarina30,Kapaki Elisabeth31,Froelich Lutz32,Ivanoiu Adrian33,Gabryelewicz Tomasz34,Verbeek Marcel M.35,Sanchez-Juan Páscual36,Hildebrandt Helmut37,Camus Vincent38,Zboch Marzena39,Brooks David J.40,Drzezga Alexander41,Rinne Juha O.42,Newberg Andrew43,de Mendonça Alexandre44,Sarazin Marie45,Rabinovici Gil D.4,Madsen Karine46,Kramberger Milica G.47,Nordberg Agneta48,Mok Vincent49,Mroczko Barbara50,Wolk David A.51,Meyer Philipp T.52,Tsolaki Magda53,Scheltens Philip2,Verhey Frans R. J.1,Visser Pieter Jelle12,Aarsland Dag54,Alcolea Daniel16,Alexander Myriam55,Almdahl Ina S.27,Arnold Steven E.51,Baldeiras Inês30,Barthel Henryk24,van Berckel Bart N.M.3,Blennow Kaj1856,van Buchem Mark A.57,Cavedo Enrica115859,Chen Kewei13,Chipi Elena25,Cohen Ann D.8,Förster Stefan60,Fortea Juan16,Frederiksen Kristian S.61,Freund-Levi Yvonne62,Gkatzima Olymbia53,Gordon Mark Forrest63,Grimmer Timo64,Hampel Harald585965,Hausner Lucrezia32,Hellwig Sabine66,Herukka Sanna-Kaisa67,Johannsen Peter68,Klimkowicz-Mrowiec Aleksandra69,Köhler Sebastian1,Koglin Norman70,van Laere Koen71,de Leon Mony72,Lisetti Viviana25,Maier Wolfgang73,Marcusson Jan74,Meulenbroek Olga75,Møllergård Hanne M.27,Morris John C.6,Nordlund Arto18,Novak Gerald P.76,Paraskevas George P.31,Perera Gayan5577,Peters Oliver78,Ramakers Inez H. G. B.1,Rami Lorena22,Rodríguez-Rodríguez Eloy36,Roe Catherine M.6,Rot Uros47,Rüther Eckart79,Santana Isabel30,Schröder Johannes80,Seo Sang W.20,Soininen Hilkka67,Spiru Luiza81,Stomrud Erik7,Struyfs Hanne19,Teunissen Charlotte E.82,Vos Stephanie J. B.1,van Waalwijk van Doorn Linda J. C.35,Waldemar Gunhild60,Wallin Åsa K.7,Wiltfang Jens79,Zetterberg Henrik185683,

Affiliation:

1. Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, the Netherlands

2. Department of Neurology and Alzheimer Center, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, the Netherlands

3. Department of Radiology and Nuclear Medicine, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, the Netherlands

4. Department of Neurology, Memory and Aging Center, University of California, San Francisco

5. Helen Wills Neuroscience Institute, University of California, Berkeley

6. Knight Alzheimer’s Disease Research Center, Department of Neurology, Washington University School of Medicine, St Louis, Missouri

7. Clinical Memory Research Unit, Clinical Sciences Malmö, Lund University, Lund, Sweden

8. Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania

9. Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, the Netherlands

10. Department of Nuclear Medicine and Centre for PET, Austin Health, Melbourne, Australia

11. Laboratory of Alzheimer's Neuroimaging and Epidemiology, IRCCS Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy

12. Memory Clinic and LANVIE–Laboratory of Neuroimaging of Aging, University Hospitals, and University of Geneva, Geneva, Switzerland

13. Banner Alzheimer’s Institute, Phoenix, Arizona

14. Eli Lilly and Company, Indianapolis, Indiana

15. Department of Neurosciences, University of California, San Diego

16. Neurology Department, Hospital de Sant Pau, Barcelona, Spain

17. Avid Radiopharmaceuticals, Philadelphia, Pennsylvania

18. Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Mölndal, Sweden

19. Reference Center for Biological Markers of Dementia (BIODEM), University of Antwerp, Antwerp, Belgium

20. Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

21. Institut National de la Santé et de la Recherche Médicale (INSERM), CHU de Caen, Caen, France

22. Alzheimer’s Disease and Other Cognitive Disorders Unit, IDIBAPS, Clinic University Hospital, Barcelona, Spain

23. Department of Psychiatry and Psychotherapy, Friedrich-Alexander University of Erlangen–Nuremberg, Erlangen, Germany

24. Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany

25. Section of Neurology, Center for Memory Disturbances, University of Perugia, Perugia, Italy

26. Department of Psychiatry, Service of Old Age Psychiatry, University Hospital of Lausanne, Lausanne, Switzerland

27. Department of Neurology, Akershus University Hospital, Lørenskog, Norway

28. Department of Neuropsychiatry, Seoul National University, College of Medicine, Seoul, South Korea

29. Laboratory for Cognitive Neurology and Alzheimer Research Centre KU Leuven, Catholic University Leuven, Leuven, Belgium

30. Center for Neuroscience and Cell Biology, Faculty of Medicine, Centro Hospitalar e Universitário de Coimbra, Portugal

31. First Department of Neurology, Eginition Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece

32. Department of Geriatric Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany

33. Memory Clinic and Neurochemistry Laboratory, Saint Luc University Hospital, Institute of Neuroscience, Université catholique de Louvain, Brussels, Belgium

34. Department of Neurodegenerative Disorders, Mossakowski Medical Research Centre Polish Academy of Sciences, Warsaw, Poland

35. Departments of Neurology and Laboratory Medicine, Donders Institute for Brain, Cognition and Behaviour, Radboud Alzheimer Center, Radboud University Medical Center, Nijmegen, the Netherlands

36. Neurology Service, Universitary Hospital Marqués de Valdecilla, IDIVAL, Santander, Spain

37. Center for Neurology, Hospital of Bremen-Ost, Bremen, Germany

38. CHRU de Tours, CIC INSERM 1415, INSERM U930, and Université François Rabelais de Tours, Tours, France

39. Alzheimer Center, Wroclaw Medical University, Scinawa, Poland

40. Division of Neuroscience, Medical Research Council Clinical Sciences Centre, Imperial College London, London, England

41. Department of Nuclear Medicine, University of Cologne, Cologne, Germany

42. Turku PET Centre and Division of Clinical Neurosciences Turku, University of Turku and Turku University Hospital, Turku, Finland

43. Myrna Brind Center of Integrative Medicine, Thomas Jefferson University and Hospital, Philadelphia, Pennsylvania

44. Institute of Molecular Medicine and Faculty of Medicine, University of Lisbon, Lisbon, Portugal

45. Neurologie de la Mémoire et du Langage, Centre Hospitalier Sainte-Anne, Université Paris 5, Paris, France

46. Neurobiology Research Unit, Copenhagen University Hospital, Copenhagen, Denmark

47. Center for Cognitive Impairments, University Medical Centre Ljubljana, Ljubljana, Slovenia

48. Department NVS, Center for Alzheimer Research, Translational Alzheimer Neurobiology, Karolinska Institutet, and Geriatric Medicine, Karolinska University Hospital, Stockholm, Sweden

49. Lui Che Woo Institute of Innovative Medicine, Department of Medicine and Therapeutics, Therese Pei Fong Chow Research Centre for Prevention of Dementia, Hong Kong

50. Department of Neurodegeneration Diagnostics, Leading National Research Centre in Białystok (KNOW), Medical University of Białystok, Białystok, Poland

51. Department of Neurology, University of Pennsylvania, Philadelphia

52. Department of Nuclear Medicine, University Hospital Freiburg, Freiburg, Germany

53. Third Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki, Greece

54. Center for Age-Related Medicine, Stavanger University Hospital, Stavanger, Norway

55. Roche Products, Welwyn Garden City, United Kingdom

56. Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden

57. Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands

58. Département de Neurologie, Institut de la Mémoire et de la Maladie d’Alzheimer (IM2A), Hôpital Pitié-Stijmsalpêtrière, Boulevard de l'hôpital, F-75013, Paris, France

59. AXA Research Fund & UPMC Chair, Sorbonne Universités, Université Pierre et Marie Curie Paris 06, Inserm, CNRS, Institut du Cerveau et de la Moelle Épinière, Paris, France

60. Department of Nuclear Medicine, Technische Universitaet München, Munich, Germany

61. Danish Dementia Research Center, Department of Neurology, Rigshospitalet, University of Copenhagen, Denmark

62. Department of Geriatrics, Karolinska University Hospital Huddinge, Section of Clinical Geriatrics, Institution of NVS, Karolinska Institutet, Stockholm, Sweden

63. Boehringer Ingelheim Pharmaceuticals, Ridgefield, Connecticut

64. Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar der Technischen Universitaet München, Munich, Germany

65. Department of Psychiatry, Alzheimer Memorial Center and Geriatric Psychiatry Branch, Ludwig-Maximilian University, Munich, Germany

66. Center of Geriatrics and Gerontology, University Hospital Freiburg, Freiburg, Germany

67. Department of Neurology, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland

68. Memory Clinic, Danish Dementia Research Center, Rigshospitalet, Copenhagen, Denmark

69. Jagiellonian University College of Medicine, Krakow, Poland

70. Piramal Imaging GmbH, Berlin, Germany

71. Department of Imaging and Pathology, Catholic University Leuven, Leuven, Belgium

72. School of Medicine, Center for Brain Health, New York University, New York

73. Department of Psychiatry and Psychotherapy, University of Bonn, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany

74. Geriatric Medicine, Department of Clinical and Experimental Medicine, University of Linköping, Linköping, Sweden

75. Department of Geriatric Medicine, Radboud Alzheimer Center, Radboud University Medical Center, Nijmegen, the Netherlands

76. Janssen Research and Development, Titusville, New Jersey

77. Department of Psychological Medicine, Institute of Psychiatry, Kings College London, London, United Kingdom

78. Department of Psychiatry and Psychotherapy, Charité Berlin, German Center for Neurodegenrative Diseases (DZNE), Berlin, Germany

79. Department of Psychiatry and Psychotherapy, University Medical Center, Georg-August University, Göttingen, Germany

80. Sektion Gerontopsychiatrie, Universität Heidelberg, Heidelberg, Germany

81. Department of Geriatrics-Gerontology-Gerontopsychiatry, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania

82. Neurochemistry Laboratory and Biobank, Department of Clinical Chemistry, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, the Netherlands

83. UCL Institute of Neurology, Queen Square, London, United Kingdom

Publisher

American Medical Association (AMA)

Subject

Psychiatry and Mental health

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