Synaptic protein CSF levels relate to memory scores in individuals without dementia-Reference-Cited by-同舟云学术

Synaptic protein CSF levels relate to memory scores in individuals without dementia

Published:2024-07-23 Issue: Volume: Page:
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Author:

Wesenhagen Kirsten E.J.¹,de Leeuw Diederick M.¹,Tomassen Jori¹,Gobom Johan²,Bos Isabelle¹,Vos Stephanie J.B.³,Martinez-Lage Pablo⁴,Tainta Mikel⁴,Popp Julius⁵,Peyratout Gwendoline⁵,Tsolaki Magda⁶,Vandenberghe Rik⁷,Freund-Levi Yvonne⁸,Verhey Frans³,Lovestone Simon⁹,Streffer Johannes¹⁰,Dobricic Valerija¹¹,Blennow Kaj¹²,Scheltens Philip¹,Smit August B.¹³,Bertram Lars¹¹,Teunissen Charlotte E.¹⁴,Zetterberg Henrik²,Tijms Betty M.¹,Visser Pieter Jelle¹,Initiative the Alzheimer’s Disease Neuroimaging

Affiliation:

1. Alzheimer Center Amsterdam, Vrije Universiteit Amsterdam, Amsterdam UMC

2. Sahlgrenska University Hospital

3. Alzheimer Center Limburg, Maastricht University

4. CITA-Alzheimer Foundation

5. University Hospital of Lausanne

6. AHEPA University Hospital, Aristotle University of Thessaloniki

7. University Hospitals Leuven

8. Karolinska Institutet

9. University of Oxford

10. University of Antwerp

11. University of Lübeck

12. University of Gothenburg

13. VU University Amsterdam

14. Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit

Abstract

INTRODUCTION: We investigated how cerebrospinal fluid levels of synaptic proteins associate with memory function in normal cognition (CN) and mild cognitive impairment (MCI), and investigated the effect of amyloid positivity on these associations. METHODS: We included 242 CN (105(43%) abnormal amyloid), and 278 MCI individuals (183(66%) abnormal amyloid) from EMIF-AD MBD and ADNI. For 181 (EMIF-AD MBD) and 36 (ADNI) proteins with a synaptic annotation in SynGO, associations with word learning recall were analysed with linear models. RESULTS: Subsets of synaptic proteins showed lower levels with worse recall in preclinical AD (EMIF-AD MBD: 7, ADNI: 5 proteins, none overlapping), prodromal AD (EMIF-AD MBD only, 27 proteins) and non-AD MCI (EMIF-AD MBD: 1, ADNI: 7 proteins). The majority of these associations were specific to these groups. DISCUSSION: Synaptic disturbance-related memory impairment occurred very early in AD, indicating it may be relevant to develop therapies targeting the synapse early in the disease.

Publisher

Springer Science and Business Media LLC

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