Interaction Testing and Polygenic Risk Scoring to Estimate the Association of Common Genetic Variants With Treatment Resistance in Schizophrenia
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Published:2022-03-01
Issue:3
Volume:79
Page:260
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ISSN:2168-622X
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Container-title:JAMA Psychiatry
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language:en
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Short-container-title:JAMA Psychiatry
Author:
Pardiñas Antonio F.1, Smart Sophie E.12, Willcocks Isabella R.1, Holmans Peter A.1, Dennison Charlotte A.1, Lynham Amy J.1, Legge Sophie E.1, Baune Bernhard T.345, Bigdeli Tim B.678, Cairns Murray J.91011, Corvin Aiden12, Fanous Ayman H.67, Frank Josef13, Kelly Brian14, McQuillin Andrew15, Melle Ingrid1617, Mortensen Preben B.1819, Mowry Bryan J.2021, Pato Carlos N.22237, Periyasamy Sathish2021, Rietschel Marcella13, Rujescu Dan2425, Simonsen Carmen1626, St Clair David27, Tooney Paul911, Wu Jing Qin28, Andreassen Ole A.1617, Kowalec Kaarina2930, Sullivan Patrick F.303132, Murray Robin M.2, Owen Michael J.1, MacCabe James H.2, O’Donovan Michael C.1, Walters James T. R.1, Ripke Stephan33, Neale Benjamin M.33, Farh Kai-How33, Lee Phil33, Bulik-Sullivan Brendan33, Collier David A.33, Huang Hailiang33, Pers Tune H.33, Agartz Ingrid33, Agerbo Esben33, Albus Margot33, Alexander Madeline33, Amin Farooq33, Bacanu Silviu A.33, Begemann Martin33, Belliveau Richard A .33, Bene Judit33, Bergen Sarah E.33, Bevilacqua Elizabeth33, Black Donald W.33, Bruggeman Richard33, Buccola Nancy G.33, Buckner Randy L.33, Byerley William33, Cahn Wiepke33, Cai Guiqing33, Campion Dominique33, Cantor Rita M.33, Carr Vaughan J.33, Carrera Noa33, Catts Stanley V.33, Chambert Kimberly D.33, Chan Raymond C. K.33, Chen Ronald Y. L.33, Chen Eric Y. H.33, Cheng Wei33, Cheung Eric F. C.33, Chong Siow Ann33, Cloninger C. Robert33, Cohen David33, Cohen Nadine33, Cormican Paul33, Craddock Nick33, Crowley James J.33, Curtis David33, Davidson Michael33, Davis Kenneth L.33, Degenhardt Franziska33, Favero Jurgen Del33, DeLisi Lynn E.33, Demontis Ditte33, Dikeos Dimitris33, Dinan Timothy33, Djurovic Srdjan33, Donohoe Gary33, Drapeau Elodie33, Duan Jubao33, Dudbridge Frank33, Durmishi Naser33, Eichhammer Peter33, Eriksson Johan33, Escott-Price Valentina33, Essioux Laurent33, Farrell Martilias S.33, Franke Lude33, Freedman Robert33, Freimer Nelson B.33, Friedl Marion33, Friedman Joseph I.33, Fromer Menachem33, Genovese Giulio33, Georgieva Lyudmila33, Gershon Elliot S.33, Giegling Ina33, Giusti-Rodríguez Paola33, Godard Stephanie33, Goldstein Jacqueline I.33, Golimbet Vera33, Gopal Srihari33, Gratten Jacob33, Haan Lieuwe de33, Hammer Christian33, Hamshere Marian L.33, Hansen Mark33, Hansen Thomas33, Haroutunian Vahram33, Hartmann Annette M.33, Henskens Frans A.33, Herms Stefan33, Hirschhorn Joel N.33, Hoffmann Per33, Hofman Andrea33, Hollegaard Mads V.33, Hougaard David M.33, Ikeda Masashi33, Joa Inge33, Julià Antonio33, Kahn René S.33, Kalaydjieva Luba33, Karachanak-Yankova Sena33, Karjalainen Juha33, Kavanagh David33, Keller Matthew C.33, Kennedy James L.33, Khrunin Andrey33, Kim Yunjung33, Klovins Janis33, Knowles James A.33, Konte Bettina33, Kucinskas Vaidutis33, Kucinskiene Zita Ausrele33, Kuzelova-Ptackova Hana33, Kähler Anna K.33, Laurent Claudine33, Keong Jimmy Lee Chee33, Lee S. Hong33, Lerer Bernard33, Li Miaoxin33, Li Tao33, Liang Kung-Yee33, Lieberman Jeffrey33, Limborska Svetlana33, Loughland Carmel M.33, Lubinski Jan33, Lönnqvist Jouko33, Macek Milan33, Magnusson Patrik K. E.33, Maher Brion S.33, Maier Wolfgang33, Mallet Jacques33, Marsal Sara33, Mattheisen Manuel33, Mattingsdal Morten33, McCarley Robert W.33, McDonald Colm33, McIntosh Andrew M.33, Meier Sandra33, Meijer Carin J.33, Melegh Bela33, Melle Ingrid33, Mesholam-Gately Raquelle I.33, Metspalu Andres33, Michie Patricia T.33, Milani Lili33, Milanova Vihra33, Mokrab Younes33, Morris Derek W.33, Mors Ole33, Murphy Kieran C.33, Myin-Germeys Inez33, Müller-Myhsok Bertram33, Nelis Mari33, Nenadic Igor33, Nertney Deborah A.33, Nestadt Gerald33, Nicodemus Kristin K.33, Nikitina-Zake Liene33, Nisenbaum Laura33, Nordin Annelie33, O’Callaghan Eadbhard33, O’Dushlaine Colm33, O’Neill F. Anthony33, Oh Sang-Yun33, Olincy Ann33, Olsen Line33, Os Jim Van33, Pantelis Christos33, Papadimitriou George N.33, Papiol Sergi33, Parkhomenko Elena33, Pato Michele T.33, Paunio Tiina33, Pejovic-Milovancevic Milica33, Perkins Diana O.33, Pietiläinen Olli33, Pimm Jonathan33, Pocklington Andrew J.33, Powell John33, Price Alkes33, Pulver Ann E.33, Purcell Shaun M.33, Quested Digby33, Rasmussen Henrik B.33, Reichenberg Abraham33, Reimers Mark A.33, Richards Alexander L.33, Roffman Joshua L.33, Roussos Panos33, Ruderfer Douglas M.33, Salomaa Veikko33, Sanders Alan R.33, Schall Ulrich33, Schubert Christian R.33, Schulze Thomas G.33, Schwab Sibylle G.33, Scolnick Edward M.33, Scott Rodney J.33, Seidman Larry J.33, Shi Jianxin33, Sigurdsson Engilbert33, Silagadze Teimuraz33, Silverman Jeremy M.33, Sim Kang33, Slominsky Petr33, Smoller Jordan W.33, So Hon-Cheong33, Spencer Chris C. A.33, Stahl Eli A.33, Stefansson Hreinn33, Steinberg Stacy33, Stogmann Elisabeth33, Straub Richard E.33, Strengman Eric33, Strohmaier Jana33, Stroup T. Scott33, Subramaniam Mythily33, Suvisaari Jaana33, Svrakic Dragan M.33, Szatkiewicz Jin P.33, Söderman Erik33, Thirumalai Srinivas33, Toncheva Draga33, Tosato Sarah33, Veijola Juha33, Waddington John33, Walsh Dermot33, Wang Dai33, Wang Qiang33, Webb Bradley T.33, Weiser Mark33, Wildenauer Dieter B.33, Williams Nigel M.33, Williams Stephanie33, Witt Stephanie H.33, Wolen Aaron R.33, Wong Emily H. M.33, Wormley Brandon K.33, Xi Hualin Simon33, Zai Clement C.33, Zheng Xuebin33, Zimprich Fritz33, Wray Naomi R.33, Stefansson Kari33, Visscher Peter M.33, Adolfsson Rolf33, Blackwood Douglas H. R.33, Bramon Elvira33, Buxbaum Joseph D.33, Børglum Anders D.33, Cichon Sven33, Darvasi Ariel33, Domenici Enrico33, Ehrenreich Hannelore33, Esko Tõnu33, Gejman Pablo V.33, Gill Michael33, Gurling Hugh33, Hultman Christina M.33, Iwata Nakao33, Jablensky Assen V.33, Jönsson Erik G.33, Kendler Kenneth S.33, Kirov George33, Knight Jo33, Lencz Todd33, Levinson Douglas F.33, Li Qingqin S.33, Liu Jianjun33, Malhotra Anil K.33, McCarroll Steven A.33, Moran Jennifer L.33, Mortensen Preben B.33, Nöthen Markus M.33, Ophoff Roel A.33, Palotie Aarno33, Petryshen Tracey L.33, Posthuma Danielle33, Riley Brien P.33, Sham Pak C.33, Sklar Pamela33, Clair David St33, Weinberger Daniel R.33, Wendland Jens R.33, Werge Thomas33, Daly Mark J.33, Agbedjro Deborah33, Stahl Daniel33, Kapur Shitij33, Millgate Edward33, Kepinska Adrianna33, Kravariti Eugenia33, Ajnakina Olesya3435, Alameda Luis2363738, Barnes Thomas R. E.39, Berardi Domenico40, Bonora Elena41, Camporesi Sara3842, Cleusix Martine42, Conus Philippe38, Crespo-Facorro Benedicto3637, D’Andrea Giuseppe40, Demjaha Arsime2, Do Kim Q.42, Doody Gillian A.43, Eap Chin B.44454647, Ferchiou Aziz48, Di Forti Marta4950, Guidi Lorenzo41, Homman Lina5152, Jenni Raoul42, Joyce Eileen M.53, Kassoumeri Laura2, Khadimallah Inès42, Lastrina Ornella40, Muratori Roberto41, Noyan Handan54, O’Neill Francis A.52, Pignon Baptiste4855, Restellini Romeo3842, Richard Jean-Romain48, Schürhoff Franck4855, Španiel Filip5657, Szöke Andrei4855, Tarricone Ilaria41, Tortelli Andrea4858, Üçok Alp59, Vázquez-Bourgon Javier606162,
Affiliation:
1. MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, United Kingdom 2. Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, United Kingdom 3. Department of Psychiatry, University of Münster, Münster, Germany 4. Department of Psychiatry, Melbourne Medical School, The University of Melbourne, Melbourne, Australia 5. The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Australia 6. Department of Psychiatry and the Behavioral Sciences, State University of New York Downstate Medical Center, Brooklyn 7. Institute for Genomic Health, State University of New York Downstate Medical Center, Brooklyn 8. Department of Psychiatry, Veterans Affairs New York Harbor Healthcare System, Brooklyn 9. School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, Australia 10. Centre for Brain and Mental Health Research, University of Newcastle, Newcastle, Australia 11. Hunter Medical Research Institute, Newcastle, Australia 12. Neuropsychiatric Genetics Research Group, Department of Psychiatry, Trinity College Dublin, Dublin, Ireland 13. Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Mannheim, Germany 14. School of Medicine & Public Health, The University of Newcastle, Newcastle, Australia 15. Molecular Psychiatry Laboratory, Division of Psychiatry, University College London, London, United Kingdom 16. Norwegian Centre for Mental Disorders Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway 17. Division of Mental Health and Addiction, Institute of Clinical Medicine, Oslo University Hospital, Oslo, Norway 18. National Centre for Register-based Research, Aarhus University, Aarhus, Denmark 19. The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark 20. Queensland Brain Institute, The University of Queensland, Brisbane, Australia 21. Queensland Centre for Mental Health Research, The University of Queensland, Brisbane, Australia 22. Department of Psychiatry and Behavioral Sciences, State University of New York Downstate Medical Center, Brooklyn 23. Department of Psychiatry and Zilkha Neurogenetics Institute, Keck School of Medicine, University of Southern California, Los Angeles 24. University Clinic and Outpatient Clinic for Psychiatry, Psychotherapy and Psychosomatics, Martin Luther University of Halle-Wittenberg, Halle, Germany 25. Division of General Psychiatry, Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria 26. Early Intervention in Psychosis Advisory Unit for South-East Norway, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway 27. Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom 28. Baker Heart and Diabetes Institute, Melbourne, Australia 29. College of Pharmacy, University of Manitoba, Winnipeg, Manitoba, Canada 30. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden 31. Department of Psychiatry, Icahn School of Medicine, Mount Sinai Hospital, New York, New York 32. Department of Genetics, University of North Carolina, Chapel Hill 33. and the Genetics Workstream of the Schizophrenia Treatment Resistance and Therapeutic Advances (STRATA) Consortium and the Schizophrenia Working Group of the Psychiatric Genomics Consortium (PGC) 34. Department of Biostatistics & Health Informatics, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, University of London, London, United Kingdom 35. Department of Behavioural Science and Health, Institute of Epidemiology and Health Care, University College London, London, United Kingdom 36. Centro de Investigacion Biomedica en Red de Salud Mental, Spanish Network for Research in Mental Health, Sevilla, Spain 37. Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocio, Departamento de Psiquiatria, Universidad de Sevilla, Sevilla, Spain 38. Treatment and Early Intervention in Psychosis Program, Service of General Psychiatry, Department of Psychiatry, Lausanne University Hospital, Lausanne, Switzerland 39. Division of Psychiatry, Imperial College London, London, United Kingdom 40. Department of Biomedical and Neuro-motor Sciences, Psychiatry Unit, Alma Mater Studiorum Università di Bologna, Bologna, Italy 41. Department of Medical and Surgical Sciences, Bologna Transcultural Psychosomatic Team, Alma Mater Studiorum, University of Bologna, Bologna, Italy 42. Unit for Research in Schizophrenia, Center for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital, Lausanne, Switzerland 43. Department of Medical Education, University of Nottingham Faculty of Medicine and Health Sciences, Nottingham, United Kingdom 44. Unit of Pharmacogenetics and Clinical Psychopharmacology, Centre for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital, University of Lausanne, Prilly, Switzerland 45. School of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland 46. Center for Research and Innovation in Clinical Pharmaceutical Sciences, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland 47. Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Geneva, Switzerland 48. University Paris-Est Créteil, Institut national de la santé et de la recherche médicale, Mondor Institute for Biomedical Research, Translational Neuropsychiatry, Fondation FondaMental, Créteil, France 49. Social Genetics and Developmental Psychiatry, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, United Kingdom 50. South London and Maudsley National Health Service Mental Health Foundation Trust, London, United Kingdom 51. Department of Social and Welfare Studies, Department of Behavioural Sciences and Learning, Linköping University, Linköping, Sweden 52. Centre For Public Health, Institute Of Clinical Sciences, Queens University Belfast, Belfast, United Kingdom 53. UCL Queen Square Institute of Neurology, University College London, London, United Kingdom 54. Faculty of Social Sciences, Department of Psychology, Beykoz University, Istanbul, Turkey 55. Assistance Publique–Hôpitaux de Paris, Hôpitaux Universitaires HMondor, Département Médico-Universitaire de Psychiatrie et d’Addictologie, Fédération Hospitalo-Universitaire de Médecine de Précision, Créteil, France 56. Department of Applied Neuroscience and Neuroimaging, National Institute of Mental Health, Klecany, Czechia 57. Department of Psychiatry and Medical Psychology, Third Faculty of Medicine, Charles University, Prague, Czechia 58. Groupe Hospitalier Universitaire Psychiatrie Neurosciences Paris, Pôle Psychiatrie Précarité, Paris, France 59. Department of Psychiatry, Istanbul University, Istanbul, Turkey 60. Department of Psychiatry, University Hospital Marques de Valdecilla-Instituto de Investigación Marques de Valdecilla, Santander, Spain 61. Department of Medicine and Psychiatry, School of Medicine, University of Cantabria, Santander, Spain 62. Centro de Investigacion Biomedica en Red de Salud Mental, Spanish Network for Research in Mental Health, Santander, Spain
Publisher
American Medical Association (AMA)
Subject
Psychiatry and Mental health
Cited by
56 articles.
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