Characterizing Heterogeneity in Neuroimaging, Cognition, Clinical Symptoms, and Genetics Among Patients With Late-Life Depression

Author:

Wen Junhao1,Fu Cynthia H. Y.23,Tosun Duygu4,Veturi Yogasudha5,Yang Zhijian1,Abdulkadir Ahmed1,Mamourian Elizabeth1,Srinivasan Dhivya1,Skampardoni Ioanna1,Singh Ashish1,Nawani Hema1,Bao Jingxuan6,Erus Guray1,Shou Haochang17,Habes Mohamad8,Doshi Jimit1,Varol Erdem9,Mackin R. Scott10,Sotiras Aristeidis11,Fan Yong1,Saykin Andrew J.12,Sheline Yvette I.13,Shen Li6,Ritchie Marylyn D.5,Wolk David A.114,Albert Marilyn15,Resnick Susan M.16,Davatzikos Christos1,Weiner Michael17,Aisen Paul17,Petersen Ronald17,Jack Clifford R.17,Jagust William17,Trojanowki John Q.17,Toga Arthur W.17,Beckett Laurel17,Green Robert C.17,Saykin Andrew J.17,Morris John17,Shaw Leslie M.17,Liu Enchi17,Montine Tom17,Thomas Ronald G.17,Donohue Michael17,Walter Sarah17,Gessert Devon17,Sather Tamie17,Jiminez Gus17,Harvey Danielle17,Bernstein Matthew17,Fox Nick17,Thompson Paul17,Schuff Norbert17,DeCArli Charles17,Borowski Bret17,Gunter Jeff17,Senjem Matt17,Vemuri Prashanthi17,Jones David17,Kantarci Kejal17,Ward Chad17,Koeppe Robert A.17,Foster Norm17,Reiman Eric M.17,Chen Kewei17,Mathis Chet17,Landau Susan17,Cairns Nigel J.17,Reinwald Lisa Taylor17,Lee Virginia17,Korecka Magdalena17,Figurski Michal17,Crawford Karen17,Neu Scott17,Foroud Tatiana M.17,Potkin Steven17,Shen Li17,Kelley Faber17,Kim Sungeun17,Nho Kwangsik17,Kachaturian Zaven17,Frank Richard17,Snyder Peter J.17,Molchan Susan17,Kaye Jeffrey17,Quinn Joseph17,Lind Betty17,Carter Raina17,Dolen Sara17,Schneider Lon S.17,Pawluczyk Sonia17,Beccera Mauricio17,Teodoro Liberty17,Spann Bryan M.17,Brewer James17,Vanderswag Helen17,Fleisher Adam17,Heidebrink Judith L.17,Lord Joanne L.17,Mason Sara S.17,Albers Colleen S.17,Knopman David17,Johnson Kris17,Doody Rachelle S.17,Meyer Javier Villanueva17,Chowdhury Munir17,Rountree Susan17,Dang Mimi17,Stern Yaakov17,Honig Lawrence S.17,Bell Karen L.17,Ances Beau17,Morris John C.17,Carroll Maria17,Leon Sue17,Householder Erin17,Mintun Mark A.17,Schneider Stacy17,Oliver Angela17,Marson Daniel17,Griffith Randall17,Clark David17,Geldmacher David17,Brockington John17,Roberson Erik17,Grossman Hillel17,Mitsis Effie17,deToledo-Morrell Leyla17,Shah Raj C.17,Duara Ranjan17,Varon Daniel17,Greig Maria T.17,Roberts Peggy17,Albert Marilyn17,Onyike Chiadi17,DAgostino II Daniel17,Kielb Stephanie17,Galvin James E.17,Pogorelec Dana M.17,Cerbone Brittany17,Michel Christina A.17,Rusinek Henry17,Leon Mony J de17,Glodzik Lidia17,Santi Susan De17,Doraiswamy P. Murali17,Petrella Jeffrey R.17,Wong Terence Z.17,Arnold Steven E.17,Karlawish Jason H.17,Wolk David17,Smith Charles D.17,Jicha Greg17,Hardy Peter17,Sinha Partha17,Oates Elizabeth17,Conrad Gary17,Lopez Oscar L.17,Oakley MaryAnn17,Simpson Donna M.17,Porsteinsson Anton P.17,Goldstein Bonnie S.17,Martin Kim17,Makino Kelly M.17,Ismail M. Saleem17,Brand Connie17,Mulnard Ruth A.17,Thai Gaby17,Ortiz Catherine Mc Adams17,Womack Kyle17,Mathews Dana17,Quiceno Mary17,Arrastia Ramon Diaz17,King Richard17,Weiner Myron17,Cook Kristen Martin17,DeVous Michael17,Levey Allan I.17,Lah James J.17,Cellar Janet S.17,Burns Jeffrey M.17,Anderson Heather S.17,Swerdlow Russell H.17,Apostolova Liana17,Tingus Kathleen17,Woo Ellen17,Silverman Daniel H.S.17,Lu Po H.17,Bartzokis George17,Radford Neill R Graff17,Parfitt Francine17,Kendall Tracy17,Johnson Heather17,Farlow Martin R.17,Hake Ann Marie17,Matthews Brandy R.17,Herring Scott17,Hunt Cynthia17,Dyck Christopher H. van17,Carson Richard E.17,MacAvoy Martha G.17,Chertkow Howard17,Bergman Howard17,Hosein Chris17,Black Sandra17,Stefanovic Bojana17,Caldwell Curtis17,Hsiung Ging Yuek Robin17,Feldman Howard17,Mudge Benita17,Assaly Michele17,Kertesz Andrew17,Rogers John17,Trost Dick17,Bernick Charles17,Munic Donna17,Kerwin Diana17,Mesulam Marek Marsel17,Lipowski Kristine17,Wu Chuang Kuo17,Johnson Nancy17,Sadowsky Carl17,Martinez Walter17,Villena Teresa17,Turner Raymond Scott17,Johnson Kathleen17,Reynolds Brigid17,Sperling Reisa A.17,Johnson Keith A.17,Marshall Gad17,Frey Meghan17,Yesavage Jerome17,Taylor Joy L.17,Lane Barton17,Rosen Allyson17,Tinklenberg Jared17,Sabbagh Marwan N.17,Belden Christine M.17,Jacobson Sandra A.17,Sirrel Sherye A.17,Kowall Neil17,Killiany Ronald17,Budson Andrew E.17,Norbash Alexander17,Johnson Patricia Lynn17,Obisesan Thomas O.17,Wolday Saba17,Allard Joanne17,Lerner Alan17,Ogrocki Paula17,Hudson Leon17,Fletcher Evan17,Carmichael Owen17,Olichney John17,DeCarli Charles17,Kittur Smita17,Borrie Michael17,Lee T Y17,Bartha Dr Rob17,Johnson Sterling17,Asthana Sanjay17,Carlsson Cynthia M.17,Potkin Steven G.17,Preda Adrian17,Nguyen Dana17,Tariot Pierre17,Reeder Stephanie17,Bates Vernice17,Capote Horacio17,Rainka Michelle17,Scharre Douglas W.17,Kataki Maria17,Adeli Anahita17,Zimmerman Earl A.17,Celmins Dzintra17,Brown Alice D.17,Pearlson Godfrey D.17,Blank Karen17,Anderson Karen17,Santulli Robert B.17,Kitzmiller Tamar J.17,Schwartz Eben S.17,Sink Kaycee M.17,Williamson Jeff D.17,Garg Pradeep17,Watkins Franklin17,Ott Brian R.17,Querfurth Henry17,Tremont Geoffrey17,Salloway Stephen17,Malloy Paul17,Correia Stephen17,Rosen Howard J.17,Miller Bruce L.17,Mintzer Jacobo17,Spicer Kenneth17,Bachman David17,Finger Elizabether17,Pasternak Stephen17,Rachinsky Irina17,Drost Dick17,Pomara Nunzio17,Hernando Raymundo17,Sarrael Antero17,Schultz Susan K.17,Ponto Laura L. Boles17,Shim Hyungsub17,Smith Karen Elizabeth17,Relkin Norman17,Chaing Gloria17,Raudin Lisa17,Smith Amanda17,Fargher Kristin17,Raj Balebail Ashok17,

Affiliation:

1. Center for Biomedical Image Computing and Analytics, Perelman School of Medicine, University of Pennsylvania, Philadelphia

2. University of East London, School of Psychology, London, United Kingdom

3. Centre for Affective Disorders, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, United Kingdom

4. Department of Radiology and Biomedical Imaging, University of California, San Francisco

5. Department of Genetics and Institute for Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia

6. Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia

7. Penn Statistics in Imaging and Visualization Center, Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia

8. Glenn Biggs Institute for Alzheimer’s & Neurodegenerative Diseases, University of Texas Health Science Center at San Antonio, San Antonio

9. Department of Statistics, Center for Theoretical Neuroscience, Zuckerman Institute, Columbia University, New York, New York

10. Department of Psychiatry and Behavioral Sciences, University of California, San Francisco

11. Department of Radiology and Institute for Informatics, Washington University School of Medicine, St Louis, Missouri

12. Radiology and Imaging Sciences, Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana Alzheimer’s Disease Research Center and the Melvin and Bren Simon Cancer Center, Indiana University School of Medicine, Indianapolis

13. Center for Neuromodulation in Depression and Stress, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia

14. Department of Neurology and Penn Memory Center, University of Pennsylvania, Philadelphia

15. Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland

16. Laboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, Maryland

17. for the iSTAGING consortium, ADNI, BIOCARD, and BLSA

Publisher

American Medical Association (AMA)

Subject

Psychiatry and Mental health

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