EFFECT OF NORETHISTERONE ACETATE, DIMETHYLSTILBOESTROL, GENISTEIN AND COUMESTROL ON UPTAKE OF [3H]OESTRADIOL BY UTERUS, VAGINA AND SKELETAL MUSCLE OF IMMATURE MICE

Abstract

SUMMARY Both norethisterone acetate and coumestrol enhanced uptake of [3H]oestradiol by the uterus and vagina measured 1 hr. after injection of the two compounds; the effect was, however, transient. Otherwise all the weak utero-vaginotrophic compounds markedly inhibited uptake of [3H]oestradiol by the uterus and vagina. This inhibition and the accompanying growth responses give further support to the conclusion that the interaction in uterine and vaginal tissue between oestradiol and the weaker utero-vaginotrophic compounds studied involves competition for retention at receptor sites followed by expression of the activity characteristic of the compounds retained.