INHIBITION OF BOVINE GROWTH HORMONE ACTIVITY BY ACETYL PROTEINS

Abstract

SUMMARY Bovine growth hormone (BGH) was acetylated with acetic anhydride under a variety of conditions and the optimal conditions defined to obtain a growth hormone inhibitor. Acetyl BGH as well as acetyl thyrotrophin, acetyl bovine serum albumin and acetyl lactalbumin in equivalent doses inhibited the growth response of hypophysectomized and intact rats to unmodified bovine growth hormone. N-acetyl dl-proline and O-acetyl dl-serine of many amino and hydroxyl acetyl amino acids also inhibited BGH but in a higher molar dose than that of the acetyl proteins.