INHIBITION OF LIPOLYTIC ACTIVITY OF HUMAN GROWTH HORMONE WITH SHEEP PROLACTIN DERIVATIVE (ANAPROLACTIN)

Abstract

ABSTRACT An acute experiment involving the suppressing of the lipolytic activity of human growth hormone (HGH) with sheep acetyl prolactin has been carried out. The experiment is based on the similarity of the physicochemical properties of native sheep prolactin and human somatotrophin. The derivative obtained inhibits the lipolytic activity of HGH to the same extent as acetylated and iodinated human somatotrophin. Similarly modified albumin and casein appear to produce no inhibitory effect, thus revealing the specific character of the anti-hormonal effect of hormone derivatives obtained. There is good reason for believing that acetylated sheep prolactin (anaprolactin) is a competing anahormone. The data on three types of anahormones are discussed.