Testosterone Pathway Genetic Polymorphisms in Relation to Primary Open-Angle Glaucoma: An Analysis in Two Large Datasets

Author:

Bailey Jessica N. Cooke12,Gharahkhani Puya3,Kang Jae H.4,Butkiewicz Mariusz12,Sullivan David A.5,Weinreb Robert N.6,Aschard Hugues7,Allingham R. Rand8,Ashley-Koch Allison9,Lee Richard K.10,Moroi Sayoko E.11,Brilliant Murray H.12,Wollstein Gadi13,Schuman Joel S.13,Fingert John H.14,Budenz Donald L.15,Realini Tony16,Gaasterland Terry17,Scott William K.18,Singh Kuldev19,Sit Arthur J.20,Igo Robert P.1,Song Yeunjoo E.12,Hark Lisa21,Ritch Robert22,Rhee Douglas J.23,Vollrath Douglas24,Zack Donald J.25,Medeiros Felipe6,Vajaranant Thasarat S.26,Chasman Daniel I.27,Christen William G.27,Pericak-Vance Margaret A.18,Liu Yutao28,Kraft Peter729,Richards Julia E.11,Rosner Bernard A.429,Hauser Michael A.89,Craig Jamie E.30,Burdon Kathryn P.31,Hewitt Alex W.32,Mackey David A.3132,Haines Jonathan L.12,MacGregor Stuart3,Wiggs Janey L.33,Pasquale Louis R.433,

Affiliation:

1. Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States

2. Institute for Computational Biology, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States

3. Statistical Genetics, QIMR Berghofer Medical Research Institute, Royal Brisbane Hospital, Brisbane, Australia

4. Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States

5. Schepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, United States

6. Department of Ophthalmology, Hamilton Glaucoma Center and Shiley Eye Institute, University of California at San Diego, La Jolla, California, United States

7. Department of Epidemiology, Harvard T. H. Chan School of Public Health, Harvard Medical School, Boston, Massachusetts, United States

8. Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina, United States

9. Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States

10. Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States

11. Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan, United States

12. Center for Human Genetics, Marshfield Clinic Research Institute, Marshfield, Wisconsin, United States

13. Department of Ophthalmology, NYU Langone Medical Center, NYU School of Medicine, New York, New York, United States

14. Departments of Ophthalmology and Anatomy/Cell Biology, University of Iowa, College of Medicine, Iowa City, Iowa, United States

15. Department of Ophthalmology, University of North Carolina, Chapel Hill, North Carolina, United States

16. Department of Ophthalmology, WVU Eye Institute, Morgantown, West Virginia, United States

17. Scripps Genome Center, University of California at San Diego, San Diego, California, United States

18. Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, United States

19. Department of Ophthalmology, Stanford University, Palo Alto, California, United States

20. Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota, United States

21. Wills Eye Hospital, Glaucoma Research Center, Philadelphia, Pennsylvania, United States

22. Einhorn Clinical Research Center, New York Eye and Ear Infirmary of Mount Sinai, New York, New York, United States

23. Department of Ophthalmology, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States

24. Department of Genetics, Stanford University, Palo Alto, California, United States

25. Wilmer Eye Institute, Johns Hopkins University Hospital, Baltimore, Maryland, United States

26. Department of Ophthalmology, University of Illinois College of Medicine at Chicago, Chicago, Illinois, United States

27. Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States

28. Department of Cellular Biology and Anatomy, Augusta University, Augusta, Georgia, United States

29. Department of Biostatistics, Harvard T. H. Chan School of Public Health, Harvard Medical School, Boston, Massachusetts, United States

30. Department of Ophthalmology, Flinders University, Adelaide, SA, Australia

31. School of Medicine, Menzies Research Institute of Tasmania, Hobart, Australia

32. Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth, Australia

33. Department of Ophthalmology, Mass Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, United States

Publisher

Association for Research in Vision and Ophthalmology (ARVO)

Subject

General Medicine

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