Hypertrophic cardiomyopathy: Translating cellular cross talk into therapeutics-Reference-Cited by-同舟云学术

Hypertrophic cardiomyopathy: Translating cellular cross talk into therapeutics

Published:2012-10-29 Issue:3 Volume:199 Page:417-421
ISSN:1540-8140
Container-title:Journal of Cell Biology
language:en
Short-container-title:

Author:

Teekakirikul Polakit¹,Padera Robert F.²,Seidman J.G.¹,Seidman Christine E.¹²³

Affiliation:

1. Department of Genetics, Harvard Medical School, Boston, MA 02115

2. Department of Pathology and Cardiovascular Division, Brigham and Women’s Hospital, Boston, MA 02115

3. Howard Hughes Medical Institute, Boston, MA 02115

Abstract

Hypertrophic cardiomyopathy (HCM) is a common inherited heart disease with serious adverse outcomes, including heart failure, arrhythmias, and sudden cardiac death. The discovery that mutations in sarcomere protein genes cause HCM has enabled the development of mouse models that recapitulate clinical manifestations of disease. Studies in these models have provided unexpected insights into the biophysical and biochemical properties of mutated contractile proteins and may help to improve clinical diagnosis and management of patients with HCM.

Publisher

Rockefeller University Press

Subject

Cell Biology

Link

http://rupress.org/jcb/article-pdf/199/3/417/1358032/jcb_201207033.pdf

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