TRPA1-dependent calcium transients and CGRP release in DRG neurons require extracellular calcium-Reference-Cited by-同舟云学术

TRPA1-dependent calcium transients and CGRP release in DRG neurons require extracellular calcium

Published:2020-05-20 Issue:6 Volume:219 Page:
ISSN:0021-9525
Container-title:Journal of Cell Biology
language:en
Short-container-title:

Author:

Gebhardt Lisa A.¹^ORCID,Kichko Tetyana I.¹^ORCID,Fischer Michael J.M.²^ORCID,Reeh Peter W.¹^ORCID

Affiliation:

1. Institute of Physiology & Pathophysiology, Friedrich-Alexander-University of Erlangen-Nürnberg, Erlangen, Germany

2. Center of Physiology & Pharmacology, Medical University, Vienna, Austria

Abstract

Shang et al. (2016. J. Cell Biol.https://doi.org/10.1083/jcb.201603081) reported that activation of lysosomal TRPA1 channels led to intracellular calcium transients and CGRP release from DRG neurons. We argue that both findings are more likely due to influx of insufficiently buffered extracellular calcium rather than lysosomal release.

Funder

Deutsche Forschungsgemeinschaft

Publisher

Rockefeller University Press

Subject

Cell Biology

Link

http://rupress.org/jcb/article-pdf/doi/10.1083/jcb.201702151/1405786/jcb_201702151.pdf

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