Paraspeckles: nuclear bodies built on long noncoding RNA-Reference-Cited by-同舟云学术

Paraspeckles: nuclear bodies built on long noncoding RNA

Published:2009-08-31 Issue:5 Volume:186 Page:637-644
ISSN:1540-8140
Container-title:Journal of Cell Biology
language:en
Short-container-title:

Author:

Bond Charles S.¹,Fox Archa H.¹

Affiliation:

1. School of Biomedical, Biomolecular, and Chemical Sciences and Western Australian Institute for Medical Research, Centre for Medical Research, University of Western Australia, Crawley, Western Australia 6009, Australia

Abstract

Paraspeckles are ribonucleoprotein bodies found in the interchromatin space of mammalian cell nuclei. These structures play a role in regulating the expression of certain genes in differentiated cells by nuclear retention of RNA. The core paraspeckle proteins (PSF/SFPQ, P54NRB/NONO, and PSPC1 [paraspeckle protein 1]) are members of the DBHS (Drosophila melanogaster behavior, human splicing) family. These proteins, together with the long nonprotein-coding RNA NEAT1 (MEN-ε/β), associate to form paraspeckles and maintain their integrity. Given the large numbers of long noncoding transcripts currently being discovered through whole transcriptome analysis, paraspeckles may be a paradigm for a class of subnuclear bodies formed around long noncoding RNA.

Publisher

Rockefeller University Press

Subject

Cell Biology

Link

http://rupress.org/jcb/article-pdf/186/5/637/1343963/jcb_200906113.pdf

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