Not just protons: Chloride also activates lysosomal acidic hydrolases-Reference-Cited by-同舟云学术

Not just protons: Chloride also activates lysosomal acidic hydrolases

Published:2023-05-16 Issue:6 Volume:222 Page:
ISSN:0021-9525
Container-title:Journal of Cell Biology
language:en
Short-container-title:

Author:

Feng Xinghua¹²,Liu Siyu²³,Xu Haoxing¹²⁴^ORCID

Affiliation:

1. The Second Affiliated Hospital of Zhejiang University School of Medicine 1 Department of Neurology and Department of Cardiology, , Hangzhou, China

2. Zhejiang University 2 Liangzhu Laboratory and School of Basic Medical Sciences, , Hangzhou, China

3. International School of Medicine, Zhejiang University 3 , Yiwu, China

4. University of Michigan 4 Department of Molecular, Cellular, and Developmental Biology, , Ann Arbor, MI, USA

Abstract

Lysosomal hydrolases require an acidic lumen for their optimal activities. In this issue, two independent groups (Wu et al. 2023. J. Cell Biol.https://doi.org/10.1083/jcb.202208155; Zhang et al. 2023. J. Cell. Biol.https://doi.org/10.1083/jcb.202210063) report that hydrolase activation also requires high intralysosomal Cl−, which is established by the lysosomal Cl−/H+ exchanger ClC-7.

Funder

Zhejiang University

Liangzhu Laboratory

National Key Research and Development Program of China

Publisher

Rockefeller University Press

Subject

Cell Biology

Link

https://rupress.org/jcb/article-pdf/doi/10.1083/jcb.202305007/1452484/jcb_202305007.pdf

Reference12 articles.

1. Lysosomes as dynamic regulators of cell and organismal homeostasis