TP53 loss‑of‑function mutations reduce sensitivity of acute leukaemia to the curaxin CBL0137
Author:
Affiliation:
1. Cancer Program, Precision Medicine Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, South Australia 5000, Australia
Publisher
Spandidos Publications
Subject
Cancer Research,Oncology,General Medicine
Reference24 articles.
1. Pediatric acute lymphoblastic leukemia;Inaba;Haematologica,2020
2. Epidemiology of acute myeloid leukemia: Recent progress and enduring challenges;Shallis;Blood Rev,2019
3. The impact of TP53 mutations and TP53 deletions on survival varies between AML, ALL, MDS and CLL: An analysis of 3307 cases;Stengel;Leukemia,2017
4. TP53 mutations occur in 15.7% of ALL and are associated with MYC-rearrangement, low hypodiploidy, and a poor prognosis;Stengel;Blood,2014
5. The anti-cancer drugs curaxins target spatial genome organization;Kantidze;Nat Commun,2019
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