TP53 mutations occur in 15.7% of ALL and are associated with MYC-rearrangement, low hypodiploidy, and a poor prognosis

Abstract

Key Points TP53 mutations are detected in 15.7% of patients with ALL and are correlated to a low hypodiploid karyotype and to MYC-translocations. Disruption of both TP53 alleles is associated with adverse prognosis in ALL.