KR-39038, a Novel GRK5 Inhibitor, Attenuates Cardiac Hypertrophy and Improves Cardiac Function in Heart Failure-Reference-Cited by-同舟云学术

KR-39038, a Novel GRK5 Inhibitor, Attenuates Cardiac Hypertrophy and Improves Cardiac Function in Heart Failure

Published:2020-09-01 Issue:5 Volume:28 Page:482-489
ISSN:1976-9148
Container-title:Biomolecules & Therapeutics
language:en
Short-container-title:Biomolecules & Therapeutics

Author:

Lee Jeong Hyun¹,Seo Ho Won¹,Ryu Jae Yong¹,Lim Chae Jo¹²,Yi Kyu Yang¹²,Oh Kwang-Seok¹²,Lee Byung Ho¹³

Affiliation:

1. Therapeutics & Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon 34114, Republic of Korea

2. Department of Medicinal and Pharmaceutical Chemistry, University of Science and Technology, Daejeon 34113, Republic of Korea

3. Graduate School of New Drug Discovery and Development, Chungnam National University, Daejeon 34134, Republic of Korea

Funder

Korea Drug Development Fund

Publisher

The Korean Society of Applied Pharmacology

Subject

Drug Discovery,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pdf.medrang.co.kr/BT2/2020/028/BT028-05-13.pdf

Reference23 articles.

1. Myocardial G Protein Receptor–Coupled Kinase Expression Correlates With Functional Parameters and Clinical Severity in Advanced Heart Failure

2. G Protein–Coupled Receptor Kinase 5

3. Biased G Protein-Coupled Receptor Signaling: New Player in Modulating Physiology and Pathology

4. de Lucia, C., Grisanti, L. A., Ibetti, J., Lucchese, A. M., Gao, E., Tilley, D. G., Leosco, D., Ferrara, N., Rengo, G. and Koch, W. J. (2017) GRK5-mediated exacerbation of ischemic heart failure involves cardiac immune-inflammatory responses. Cir. Res. 121, A396.

5. Interrelationship Between Cardiac Hypertrophy, Heart Failure, and Chronic Kidney Disease

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