1. Clinical and Experimental Sciences, University of Southampton Faculty of Medicine, and
2. National Institute for Health Research Southampton Respiratory Biomedical Research Unit, Southampton University Hospital, Southampton, United Kingdom
3. Janssen Research and Development, High Wycombe, Buckinghamshire, United Kingdom
4. Roche, F. Hoffman–La Roche AG, Konzern-Hauptsitz, Basel, Switzerland; and
5. Nuffield Department of Medicine and National Institute for Health Research Oxford Biomedical Research Centre, University of Oxford, United Kingdom