T H 2 and T H 17 inflammatory pathways are reciprocally regulated in asthma-Reference-Cited by-同舟云学术

T H 2 and T H 17 inflammatory pathways are reciprocally regulated in asthma

Published:2015-08-19 Issue:301 Volume:7 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Choy David F.¹,Hart Kevin M.²,Borthwick Lee A.³,Shikotra Aarti⁴,Nagarkar Deepti R.¹,Siddiqui Salman⁴,Jia Guiquan¹,Ohri Chandra M.⁴,Doran Emma¹⁵,Vannella Kevin M.²,Butler Claire A.⁵,Hargadon Beverley⁴,Sciurba Joshua C.²,Gieseck Richard L.²,Thompson Robert W.²,White Sandra²,Abbas Alexander R.¹,Jackman Janet¹,Wu Lawren C.¹,Egen Jackson G.¹,Heaney Liam G.⁵,Ramalingam Thirumalai R.²,Arron Joseph R.¹,Wynn Thomas A.²,Bradding Peter⁴

Affiliation:

1. Genentech Inc., South San Francisco, CA 94080, USA.

2. Program in Tissue Immunity and Repair, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

3. Tissue Fibrosis and Repair Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.

4. Institute for Lung Health, Department of Infection, Immunity and Inflammation, University of Leicester, Leicester LE3 9QP, UK.

5. Centre for Infection and Immunity, Health Sciences Building, Queens University Belfast, Lisburn Road, Belfast BT9 7AB, Northern Ireland, UK.

Abstract

Concurrent blockade of IL-13 and IL-17A may improve control of asthma.

Funder

NIH

NIAID

Genentech Inc.

National Institute for Health Research

Asthma UK

Publisher