New Tricks for an Old Dog: Biased GPCR Agonism of an M4 Muscarinic Acetylcholine Receptor Antagonist in Airway Smooth Muscle Cells
Author:
Affiliation:
1. Department of Respiratory SciencesUniversity of LeicesterLeicester, United Kingdom
Publisher
American Thoracic Society
Subject
Cell Biology,Clinical Biochemistry,Pulmonary and Respiratory Medicine,Molecular Biology
Link
https://www.atsjournals.org/doi/pdf/10.1165/rcmb.2022-0335ED
Reference13 articles.
1. PD 102807 Induces M3 mAChR-Dependent GRK-/Arrestin-Biased Signaling in Airway Smooth Muscle Cells
2. Functional characterisation of PD102807: A novel M4-selective muscarinic antagonist
3. Pharmacological characterization of PD102807: An m4 subtype selective muscarinic antagonist
4. PD 102807, a novel muscarinic M4 receptor antagonist, discriminates between striatal and cortical muscarinic receptors coupled to cyclic AMP
5. Phenotype and Functional Features of Human Telomerase Reverse Transcriptase Immortalized Human Airway Smooth Muscle Cells from Asthmatic and Non-Asthmatic Donors
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