Tissue Proteomic Analysis Identifies Mechanisms and Stages of Immunopathology in Fatal COVID-19-Reference-Cited by-同舟云学术

Tissue Proteomic Analysis Identifies Mechanisms and Stages of Immunopathology in Fatal COVID-19

Published:2022-02 Issue:2 Volume:66 Page:196-205
ISSN:1044-1549
Container-title:American Journal of Respiratory Cell and Molecular Biology
language:en
Short-container-title:Am J Respir Cell Mol Biol

Author:

Russell Clark D.¹²^ORCID,Valanciute Asta¹,Gachanja Naomi N.¹,Stephen Jillian¹,Penrice-Randal Rebekah³^ORCID,Armstrong Stuart D.³^ORCID,Clohisey Sara²^ORCID,Wang Bo²^ORCID,Al Qsous Wael⁴^ORCID,Wallace William A.⁵,Oniscu Gabriel C.⁶,Stevens Jo²,Harrison David J.⁷^ORCID,Dhaliwal Kevin¹⁸^ORCID,Hiscox Julian A.³⁹¹⁰^ORCID,Baillie J. Kenneth²¹¹^ORCID,Akram Ahsan R.¹⁸^ORCID,Dorward David A.¹⁵^ORCID,Lucas Christopher D.¹⁸¹²^ORCID

Affiliation:

1. University of Edinburgh Centre for Inflammation Research, Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, United Kingdom;

2. Roslin Institute, University of Edinburgh, Easter Bush Campus, Midlothian, United Kingdom;

3. Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, United Kingdom;

4. Department of Pathology, Western General Hospital, Edinburgh, United Kingdom;

5. Department of Pathology,

6. Edinburgh Transplant Centre,

7. School of Medicine, University of St. Andrews, North Haugh, St. Andrews, United Kingdom;

8. Department of Respiratory Medicine, and

9. NIHR Health Protection Research Unit in Emerging and Zoonotic Infections, Liverpool, United Kingdom;

10. Infectious Diseases Horizontal Technology Centre, Agency for Science, Technology, and Research, Singapore; and

11. Intensive Care Unit, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom;

12. Institute for Regeneration and Repair, University of Edinburgh, Edinburgh BioQuarter, Edinburgh, United Kingdom

Funder

UK Research and Innovation (Coronavirus Disease [COVID-19] Rapid Response Initiative

Chief Scientist Office

Medical Research Scotland

Medical Research Council

Wellcome Trust

Publisher

American Thoracic Society

Subject

Cell Biology,Clinical Biochemistry,Pulmonary and Respiratory Medicine,Molecular Biology

Reference47 articles.

1. Tissue-Specific Immunopathology in Fatal COVID-19

2. Histopathological findings and viral tropism in UK patients with severe fatal COVID-19: a post-mortem study

3. Postmortem examination of COVID‐19 patients reveals diffuse alveolar damage with severe capillary congestion and variegated findings in lungs and other organs suggesting vascular dysfunction

4. Early postmortem mapping of SARS-CoV-2 RNA in patients with COVID-19 and the correlation with tissue damage

5. Megakaryocytes and platelet-fibrin thrombi characterize multi-organ thrombosis at autopsy in COVID-19: A case series

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