Chronic Exercise Training Down-Regulates TNF-α and Atrogin-1/MAFbx in Mouse Gastrocnemius Muscle Atrophy Induced by Hindlimb Unloading

Author:

Al-Nassan Saad1,Fujita Naoto1,Kondo Hiroyo2,Murakami Shinichiro3,Fujino Hidemi1

Affiliation:

1. Department of Rehabilitation Science, Kobe University, Graduate School of Health Sciences

2. Department of Food Sciences and Nutrition, Nagoya Women’s University

3. Department of Physical Therapy, Himeji Dokkyo University

Publisher

Japan Society of Histochemistry & Cytochemistry

Subject

Cell Biology,Histology,Physiology,Biochemistry,Pathology and Forensic Medicine

Reference39 articles.

1. 1. Adams, G. R., Haddad, F., Bodell, P. W., Tran, P. D. and Baldwin, K. M. (2007) Combined isometric, concentric, and eccentric resistance exercise prevents unloading-induced muscle atrophy in rats. J. Appl. Physiol. 103; 1644-1654.

2. 2. Allen, D. L., Linderman, J. K., Roy, R. R., Bigbee, A. J., Grindeland, R. E., Mukku, V. and Edgerton, V. R. (1997) Apoptosis: a mechanism contributing to remodeling of skeletal muscle in response to hindlimb unweighting. Am. J. Physiol. 273; C579-C587.

3. 3. Allen, D. L., Linderman, J. K., Roy, R. R., Grindeland, R. E., Mukku, V. and Edgerton, V. R. (1997) Growth hormone/IGF-I and/or resistive exercise maintains myonuclear number in hindlimb unweighted muscles. J. Appl. Physiol. 83; 1857-1861.

4. 4. Andrianjafiniony, T., Dupré-Aucouturier, S., Letexier, D., Couchoux, H. and Desplanches, D. (2010) Oxidative stress, apoptosis, and proteolysis in skeletal muscle repair after unloading. Am. J. Physiol. Cell Physiol. 299; C307-C315.

5. Determinants of Disuse-Induced Skeletal Muscle Atrophy: Exercise and Nutrition Countermeasures to Prevent Protein Loss

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