The combination of exercise and metformin inhibits TGF-β1/Smad pathway to attenuate myocardial fibrosis in db/db mice by reducing NF-κB–mediated inflammatory response

Author:

Liu Jingjing,Lu Jiao,Zhang Liumei,Liu Yuting,Zhang Yuan,Gao Yaran,Yuan Xinmeng,Xiang Mengqi,Tang QiangORCID

Publisher

Elsevier BV

Subject

Pharmacology,General Medicine

Reference51 articles.

1. Long non-coding RNA: a key regulator in the pathogenesis of diabetic cardiomyopathy;Guo;Front. Cardiovasc. Med.,2021

2. Cardiac fibrosis: myofibroblast-mediated pathological regulation and drug delivery strategies;Liu;Adv. Drug Deliv. Rev.,2021

3. Cardiac fibrosis;Frangogiannis;Cardiovasc. Res.,2021

4. Exogenous H2S mitigates myocardial fibrosis in diabetic rats through suppression of the canonical Wnt pathway;Yang;Int. J. Mol. Med.,2019

5. Insulin therapy is associated with increased myocardial interstitial fibrosis and cardiomyocyte apoptosis in a rodent model of experimental diabetes;Adel;Front. Physiol.,2022

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