New Insights into the Pathogenesis of Diabetic Nephropathy: Proximal Renal Tubules Are Primary Target of Oxidative Stress in Diabetic Kidney

Author:

Haraguchi Ryuma1,Kohara Yukihiro1,Matsubayashi Kanako1,Kitazawa Riko12,Kitazawa Sohei1

Affiliation:

1. Department of Molecular Pathology, Ehime University Graduate School of Medicine

2. Department of Diagnostic Pathology, Ehime University Hospital

Publisher

Japan Society of Histochemistry & Cytochemistry

Subject

Cell Biology,Histology,Physiology,Biochemistry,Pathology and Forensic Medicine

Reference41 articles.

1. 1 Bhargava, P. and Schnellmann, R. G. (2017) Mitochondrial energetics in the kidney. Nat. Rev. Nephrol. 13; 629–646.

2. 2 Blantz, R. C. (2014) Phenotypic characteristics of diabetic kidney involvement. Kidney Int. 86; 7–9.

3. 3 Bohlender, J. M., Franke, S., Stein, G. and Wolf, G. (2005) Advanced glycation end products and the kidney. Am. J. Physiol. Renal Physiol. 289; F645–659.

4. 4 Brunk, U. T. and Terman, A. (2002) The mitochondrial-lysosomal axis theory of aging: accumulation of damaged mitochondria as a result of imperfect autophagocytosis. Eur. J. Biochem. 269; 1996–2002.

5. 5 Chen, X., Ma, J., Kwan, T., Stribos, E. G. D., Messchendorp, A. L., Loh, Y. W., Wang, X., Paul, M., Cunningham, E. C., Habib, M., Alexander, I. E., Sharland, A. F., Chadban, S. J. and Wu, H. (2018) Blockade of HMGB1 Attenuates Diabetic Nephropathy in Mice. Sci. Rep. 8; 8319.

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