Affiliation:
1. Unité de Recherche de Chimie de l’Environnement et Moléculaire Structurale, Université frères Mentouri, Constantine 25000, Algérie
2. Equipe de Synthèse de Molécules à Objectif Thérapeutique, Laboratoire des Produits Naturels d’Origine Végétale et de Synthèse Organique, Université frères Mentouri, Constantine 25000, Algérie
Abstract
Abstract
Three benzoindolizine derivatives, 1, 2, and 3, were obtained via 1,3-dipolar cycloaddition. The reaction of 1-(2′-benzimidazolylmethyl)isoquinolinium ylides with dimethyl acetylenedicarboxylate gave a mixture of pyrrolo[2,1-a]isoquinoline-1,2-dicarboxylate (1) and 1,10b-dihydropyrrolo[2,1-a]isoquinoline-1,2-dicarboxylate (2) derivatives containing a benzimidazole moiety. The reaction of this isoquinolinium N-ylide with dimethyl maleate gave an unexpected 2,3-dihydropyrrolo[2,1-a]isoquinoline-1,2-dicarboxylate (3). The structures of all reported compounds have been examined by X-ray crystallography, mass spectrometry, and NMR spectroscopy.
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