Antifungal Activity of Coumarins-Reference-Cited by-同舟云学术

Antifungal Activity of Coumarins

Published:2008-02-01 Issue:1-2 Volume:63 Page:21-28
ISSN:1865-7125
Container-title:Zeitschrift für Naturforschung C
language:en
Short-container-title:

Author:

Montagner Cristina¹,de Souza Simone M.¹,Groposo Cláudia¹,Delle Monache Franco²,Smânia Elza F. A.¹,Smânia Jr Artur¹

Affiliation:

1. Departamento de Microbiologia e Parasitologia, Centro de Ciências Biológicas da Universidade Federal de Santa Catarina, Campus Universitário, Trindade, Florianópolis-SC 88040-900, Brazil

2. Centro Chimica dei Recettori (CNR), Universitá Cattolica del Sacro Cuore, Largo Francesco Vito, 1, Roma 00168, Italy

Abstract

The antifungal activity of 40 coumarins was tested against the fungal strains: Candida albicans (ATCC 14053), Aspergillus fumigatus (ATCC 16913) and Fusarium solani (ATCC 36031), using the broth microdilution method. Osthenol showed the most effective antifungal activity among all the compounds tested, with a MIC value of 125 μg/ml for Fusarium solani and 250 μg/ml for Candida albicans and Aspergillus fumigatus. The antifungal potential of this prenylated coumarin can be related to the presence of an alkyl group at C-8 position.

Publisher

Walter de Gruyter GmbH

Subject

General Biochemistry, Genetics and Molecular Biology

Link

https://www.degruyter.com/document/doi/10.1515/znc-2008-1-205/pdf

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