Impact of hemolysis on uracilemia in the context of dihydropyrimidine dehydrogenase deficiency testing

Author:

Loison Gaspard1,Bouges Le Royer Hélène2,Marsili Sabrina13,Brice Aurélie13,Vintejoux Julien13,Yakoubi Malika13,Sirgue Hélène13,Chatelut Etienne13,Etienne-Grimaldi Marie-Christine2,Thomas Fabienne1435ORCID

Affiliation:

1. Laboratory of Pharmacology , Oncopole Claudius Regaud , Toulouse , France

2. Laboratory of Oncopharmacology , Centre Antoine Lacassagne , Nice , France

3. Centre de Recherche en Cancérologie de Toulouse, INSERM U1037 , Université Paul Sabatier , Toulouse , France

4. University Paul Sabatier , Toulouse , France

5. Institut Universitaire du Cancer Toulouse – Oncopole , Toulouse , France

Publisher

Walter de Gruyter GmbH

Reference8 articles.

1. Ezzeldin, H, Diasio, R. Dihydropyrimidine dehydrogenase deficiency, a pharmacogenetic syndrome associated with potentially life-threatening toxicity following 5-fluorouracil administration. Clin Colorectal Cancer 2004;4:181–9. https://doi.org/10.3816/ccc.2004.n.018.

2. Barin-Le Guellec, C, Lafay-Chebassier, C, Ingrand, I, Tournamille, JF, Boudet, A, Lanoue, MC, et al.. Toxicities associated with chemotherapy regimens containing a fluoropyrimidine: a real-life evaluation in France. Eur J Cancer 2020;124:37–46. https://doi.org/10.1016/j.ejca.2019.09.028.

3. Boisdron-Celle, M, Remaud, G, Traore, S, Poirier, AL, Gamelin, L, Morel, A, et al.. 5-Fluorouracil-related severe toxicity: a comparison of different methods for the pretherapeutic detection of dihydropyrimidine dehydrogenase deficiency. Cancer Lett 2007;249:271–82. https://doi.org/10.1016/j.canlet.2006.09.006.

4. HAS. Screening for dihydropyrimidine dehydrogenase deficiency to decrease the risk of severe toxicities related to fluoropyrimidines (5-fluorouracil or capecitabine). [Internet]. Available from: https://www.has-sante.fr/upload/docs/application/pdf/2018-12/recherche_dun_deficit_en_dihydropyrimidine_deshydrogenase_visant_a_prevenir_certaines_toxicites_severes_associees_aux_traite.pdf.

5. Maillard, M, Launay, M, Royer, B, Guitton, J, Gautier-Veyret, E, Broutin, S, et al., Groupe de Pharmacologie Clinique Oncologique (GPCO). Quantitative impact of pre-analytical process on plasma uracil when testing for dihydropyrimidine dehydrogenase deficiency. Br J Clin Pharmacol 2023;89:762–72. https://doi.org/10.1111/bcp.15536.

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