The predictive value of hemoglobin to creatinine ratio for contrast-induced nephropathy in percutaneous coronary interventions
Author:
Çamci Sencer1, Kinik Mustafa1, Ari Selma1, Ari Hasan1, Melek Mehmet1, Bozat Tahsin1
Affiliation:
1. Department of Cardiology , Bursa Postgraduate Hospital , Bursa , Turkey
Abstract
Abstract
Objectives
Hemoglobin and creatinine levels are important factors for contrast induced nephropathy (CIN) development. Our aim in this study is to investigate the predictive value of hemoglobin to creatinine ratio for CIN development in patients with percutaneous coronary intervention (PCI).
Methods
A total of 500 patients who underwent PCI in our clinic were evaluated prospectively in terms of CIN. Hemoglobin to creatinine ratio is calculated as baseline hemoglobin/baseline serum creatinine value. glomerular filtration rate (GFR) was calculated with Cockcroft-Gault formula. The definition of CIN includes absolute (≥0.5 mg/dL) or relative increase (≥25%) in serum creatinine at 48–72 h after exposure to a contrast agent compared to baseline serum creatinine values.
Results
CIN was detected in 13.8% (69 patients) of 500 patients. In multivariate lineer regression analysis, hemoglobin to creatinine ratio (beta: −0.227, p=0.03) and ejection fraction (EF) (beta: −0.161, p<0.001), contrast amount used (beta: 0.231, p<0.001) were found to be significant predictors for the development of CIN. In receiver operating characteristics (ROC) analysis; AUC=0.730 (0.66–0.79) for hemoglobin to creatinine ratio, p<0.001, AUC=0.694 (0.62–0.76) for EF, p<0.001 and AUC=0.731 (0.67–0.78) for contrast amount used p<0.001.
Conclusions
Hemoglobin to creatinine ratio, EF and contrast amount used were independent predictors for CIN development in patients with PCI (NCT04703049).
Publisher
Walter de Gruyter GmbH
Subject
Biochemistry (medical),Clinical Biochemistry,General Medicine
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