Spurious results for total and free prostate-specific antigen (PSA); sometimes really “a riddle wrapped in a mystery inside an enigma”

Author:

Dorizzi Romolo Marco1ORCID,Maltoni Paolo1,Sgarzani Claudio1,Torello Monica1,Montanari Francesco2

Affiliation:

1. Clinical Pathology Unit , Hub Laboratory, AUSL Romagna , Cesena , Italy

2. Urology Unit , Rimini Hospital, AUSL Romagna , Rimini , Italy

Publisher

Walter de Gruyter GmbH

Subject

Biochemistry (medical),Clinical Biochemistry,General Medicine

Reference12 articles.

1. Ferraro, S, Biganzoli, EM. The clinical value of assessing the inter-method bias: the lesson from prostate specific antigen measurement. Clin Chem Lab Med 2022;60:149–51.

2. AACC Artery. Free prostate specific antigen. Available from: https://artery.aacc.org/communities/community-home/digestviewer/viewthread?GroupId=7&MessageKey=fd73002b-a04e-4c73-a888-9916244ae6e3&CommunityKey=723b6334-7f7c-4ed0-bc02-e38d42226ed7&tab=digestviewer&ReturnUrl=%2fcommunities%2fcommunity-home%2fdigestviewer%3ftab%3ddigestviewer%26CommunityKey%3d723b6334-7f7c-4ed0-bc02-e38d42226ed7 [Accessed 8 Feb 2022].

3. Huang, HQ, Zhang, Y, Xu, HG. Different free prostate-specific antigen to total prostate-specific antigen ratios using three detecting systems. J Clin Lab Anal 2018;32:e22231. https://doi.org/10.1002/jcla.22231.

4. Van Duijnhoven, HL, Péquériaux, NC, Van Zon, JP, Blankenstein, MA. Large discrepancy between prostate-specific antigen results from different assays during longitudinal follow-up of a prostate cancer patient. Clin Chem 1996;42:637–41. https://doi.org/10.1093/clinchem/42.4.637.

5. Park, S, Wians, FHJr, Cadeddu, JA. Spurious prostate-specific antigen (PSA) recurrence after radical prostatectomy: interference by human antimouse heterophile antibodies. Int J Urol 2007;14:251–3. https://doi.org/10.1111/j.1442-2042.2006.01648.x.

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