1. Biochemistry and Molecular Genetics Department , University Hospital , Clermont-Ferrand , France
2. Clermont Auvergne University, CNRS, INSERM, iGReD , Clermont-Ferrand , France
3. Biostatistics unit (DRCI) Department , University Hospital , Clermont-Ferrand , France
4. Service de Biochimie et Génétique Moléculaire , Centre de Biologie, CHU Gabriel Montpied , Clermont-Ferrand , France