Ad interim recommendations for diagnosing SARS-CoV-2 infection by the IFCC SARS-CoV-2 variants working group

Author:

Lippi Giuseppe123ORCID,Favresse Julien14,Gromiha Michael M.15,SoRelle Jeffrey A.16,Plebani Mario17ORCID,Henry Brandon M.18

Affiliation:

1. IFCC SARS-CoV-2 Variants Working Group , Verona , Italy

2. IFCC Task Force on COVID-19 , Verona , Italy

3. Section of Clinical Biochemistry and School of Medicine, University of Verona , Verona , Italy

4. Department of Laboratory Medicine , Clinique St-Luc Bouge , Namur , Belgium

5. Department of Biotechnology , Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras , Chennai , India

6. Department of Pathology , University of Texas Southwestern Medical Center , Dallas , TX , USA

7. Department of Medicine-DIMED , University of Padova , Padova , Italy

8. Clinical Laboratory, Division of Nephrology and Hypertension , Cincinnati Children’s Hospital Medical Center , Cincinnati , OH , USA

Abstract

Abstract This document, endorsed by the IFCC Working Group on SARS-CoV-2 Variants, aims to update previous indications for diagnosing acute SARS-CoV-2 infection, taking into consideration the evidence that has emerged after the origin and spread of new lineages and sub-lineages of the virus characterized by mutated genetics and altered biochemical, biological and clinical characteristics. These indications encompass the use of different diagnostic strategies in specific clinical settings, such as high risk of SARS-CoV-2 infection (symptomatic patients), low risk of SARS-CoV-2 infection (asymptomatic subjects) at hospital admission/contact tracing, testing in asymptomatic subjects, in epidemiologic surveys and/or population screening, along with tentative indications for identification of new lineages and/or sub-lineages of SARS-CoV-2.

Publisher

Walter de Gruyter GmbH

Subject

Biochemistry (medical),Clinical Biochemistry,General Medicine

Reference39 articles.

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2. Lippi, G, Henry, BM. The landscape of SARS-CoV-2 genomic mutations. J Lab Precis Med 2022. https://doi.org/10.21037/jlpm-22-17 [Epub ahead of print].

3. Bohn, MK, Mancini, N, Loh, TP, Wang, CB, Grimmler, M, Gramegna, M, et al.. IFCC interim guidelines on molecular testing of SARS-CoV-2 infection. Clin Chem Lab Med 2020;58:1993–2000. https://doi.org/10.1515/cclm-2020-1412.

4. World health Organization. Diagnostic testing for SARS-CoV-2. Available at: https://www.who.int/publications/i/item/diagnostic-testing-for-sars-cov-2 [Last accessed 1 Apr 2022].

5. US Centers for Disease Control and Prevention. Overview of testing for SARS-CoV-2, the virus that causes COVID-19 - updated Feb. 11, 2022. Available at: https://www.cdc.gov/coronavirus/2019-ncov/hcp/testing-overview.html#TestingInfection [Last accessed 1 Apr 2022].

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