An efficient click synthesis of chalcones derivatized with two 1-(2-quinolon-4-yl)-1,2,3-triazoles
Author:
Alshammari Mohammed B.1, Aly Ashraf A.2, Brown Alan B.3, Bakht Md Afroz1, Shawky Ahmed M.4, Abdelhakem Adel M.5, El-Sheref Essmat M.2
Affiliation:
1. Chemistry Department , College of Sciences and Humanities, Prince Sattam bin Abdulaziz University , P. O. Box 83 , Al-Kharj 11942 , Saudi Arabia 2. Department of Chemistry , Faculty of Science, Minia University , 61519 , Minia , Egypt 3. Chemistry Department , Florida Institute of Technology , 150 W University Blvd , Melbourne , FL 32901 , USA 4. Science and Technology Unit (STU) , Umm Al-Qura University , Makkah 21955 , Saudi Arabia 5. Department of Medicinal Chemistry , Faculty of Pharmacy, Minia University , 61519 , Minia , Egypt
Abstract
Abstract
Chalcones derivatized with 1-(2-quinolonyl)-1,2,3-triazoles were synthesized by reaction of 4-azido-2-quinolones with 1-phenyl-3-(4-propargyloxyphenyl)prop-2-en-1-one, or by aldol reaction of 4-{[1-(2-oxo-1,2-dihydroquinolin-4-yl)-1H-1,2,3-triazol-4-yl]methoxy}benzaldehydes with acetophenone. Whereas, chalcones bearing two 1-(2-quinolonyl)-1,2,3-triazoles were synthesized by reaction of 1,3-bis(4-propargyloxyphenyl)prop-2-en-1-one with 4-azido-2-quinolones, or by aldol condensation between 4-{4-[(4-acetylphenoxy)methyl]-1H-1,2,3-triazol-1-yl}quinolin-2(1H)-ones and 4-{[1-(2-oxo-1,2-dihydroquinolin-4-yl)-1H-1,2,3-triazol-4-yl]methoxy}benzaldehydes.
Publisher
Walter de Gruyter GmbH
Subject
General Chemistry
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