Synthesis of a new series of 4-pyrazolylquinolinones with apoptotic antiproliferative effects as dual EGFR/BRAF<sup>V600E</sup> inhibitors-Reference-Cited by-同舟云学术

Synthesis of a new series of 4-pyrazolylquinolinones with apoptotic antiproliferative effects as dual EGFR/BRAF^V600E inhibitors

Published:2024 Issue:7 Volume:15 Page:2538-2552
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Al-Wahaibi Lamya H.¹,Youssif Bahaa G. M.²^ORCID,Abou-Zied Hesham A.³,Bräse Stefan⁴^ORCID,Brown Alan B.⁵^ORCID,Tawfeek Hendawy N.⁶,El-Sheref Essmat M.⁶

Affiliation:

1. Department of Chemistry, College of Sciences, Princess Nourah bint Abdulrahman University, Riyadh 11671, Saudi Arabia

2. Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt

3. Medicinal Chemistry Department, Faculty of Pharmacy, Deraya University, Minia, Egypt

4. Institute of Biological and Chemical Systems, IBCS-FMS, Karlsruhe Institute of Technology, 76131 Karlsruhe, Germany

5. Florida Institute of Technology, 150 W University Blvd, Melbourne, FL 32901, USA

6. Chemistry Department, Faculty of Science, Minia University, El Minia, 61519 Egypt

Abstract

A series of new pyrazolylquinolin-2-ones were designed and synthesised. The structures of the new compounds were validated by IR, NMR, and elemental analysis. The new compounds were evaluated as antiproliferative agents targeting EGFR and BRAFV600E.

Funder

Deanship of Scientific Research, Princess Nourah Bint Abdulrahman University

Karlsruhe Institute of Technology

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/MD/D4MD00230J

Reference66 articles.

1. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

2. Cell survival and metastasis regulation by Akt signaling in colorectal cancer

3. AKTivation mechanisms

4. Revisiting protein kinase–substrate interactions: Toward therapeutic development

5. J. M.Drake , J. K.Lee and O. N.Witte , Molecular and cellular biology , 2014