Explainable AI for gut microbiome-based diagnostics: colorectal cancer as a case study
Author:
Affiliation:
1. Institute of Cancer and Genomic Sciences, University of Birmingham , Birmingham , UK
2. Institute of Translational Medicine, University of Birmingham , Birmingham , UK
3. MRC Health Data Research UK (HDR UK), Midlands Site , Birmingham , UK
Publisher
Walter de Gruyter GmbH
Subject
Biochemistry (medical),Clinical Biochemistry,Public Health, Environmental and Occupational Health,Health Policy,Medicine (miscellaneous)
Link
https://www.degruyter.com/document/doi/10.1515/dx-2023-0062/pdf
Reference10 articles.
1. Roelands, J, Kuppen, PJK, Ahmed, EI, Mall, R, Masoodi, T, Singh, P, et al.. An integrated tumor, immune and microbiome atlas of colon cancer. Nat Med 2023;29:1273–86. https://doi.org/10.1038/s41591-023-02324-5.
2. Rebersek, M. Gut microbiome and its role in colorectal cancer. BMC Cancer 2021;21:1325. https://doi.org/10.1186/s12885-021-09054-2.
3. Ternes, D, Karta, J, Tsenkova, M, Wilmes, P, Haan, S, Letellier, E. Microbiome in colorectal cancer: how to get from meta-omics to mechanism? Trends Microbiol 2020;28:401–23. https://doi.org/10.1016/j.tim.2020.05.013.
4. Bosch, S, Acharjee, A, Quraishi, MN, Bijnsdorp, IV, Rojas, P, Bakkali, A, et al.. Integration of stool microbiota, proteome and amino acid profiles to discriminate patients with adenomas and colorectal cancer. Gut Microb 2022;14:2139979. https://doi.org/10.1080/19490976.2022.2139979.
5. Acharjee, A, Larkman, J, Xu, Y, Cardoso, VR, Gkoutos, GV. A random forest based biomarker discovery and power analysis framework for diagnostics research. BMC Med Genom 2020;13:178. https://doi.org/10.1186/s12920-020-00826-6.
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