Integration of stool microbiota, proteome and amino acid profiles to discriminate patients with adenomas and colorectal cancer

Author:

Bosch Sofie1ORCID,Acharjee Animesh234,Quraishi Mohammed Nabil5678,Bijnsdorp Irene V910,Rojas Patricia11,Bakkali Abdellatif12,Jansen Erwin EW12,Stokkers Pieter13,Kuijvenhoven Johan14,Pham Thang V9,Beggs Andrew D6,Jimenez Connie R9,Struys Eduard A12,Gkoutos Georgios V2341516,de Meij Tim GJ17,de Boer Nanne KH1

Affiliation:

1. Department of Gastroenterology and Hepatology, Amsterdam Gastroenterology and Endocrinology Metabolism Institute, Amsterdam University Medical Centre, VU University Amsterdam, Amsterdam, The Netherlands

2. College of Medical and Dental Sciences, Institute of Cancer and Genomic Sciences, Center for Computational Biology, University of Birmingham, Birmingham, UK

3. Institute of Translational Medicine, University Hospitals Birmingham NHS, Foundation Trust, UK

4. NIHR Surgical Reconstruction and Microbiology Research Center, University Hospital Birmingham, Birmingham, UK

5. Department of Gastroenterology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK

6. Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK

7. Microbiome Treatment Center, University of Birmingham Microbiome Treatment Center, University of Birmingham, UK

8. Center for Liver and Gastroenterology Research, NIHR Birmingham Biomedical Research Center, University of Birmingham, Birmingham, UK

9. Department of Medical Oncology, Amsterdam UMC, VU University Medical Center, Amsterdam, The Netherlands

10. Department of Urology, Amsterdam UMC, Cancer Center Amsterdam, Amsterdam, The Netherlands

11. Institute of Applied Health Research, University of Birmingham, Birmingham, UK

12. Department of Clinical Chemistry, VU University Medical Center, Amsterdam, The Netherlands

13. Department of Gastroenterology and Hepatology, OLVG West, Amsterdam, The Netherlands

14. Spaarne Gasthuis, Department of Gastroenterology and Hepatology, Hoofddorp and Haarlem, The Netherlands

15. Microbiome Treatment Center, MRC Health Data Research UK (HDR UK), Birmingham, UK

16. Microbiome Treatment Center, NIHR Experimental Cancer Medicine Center, Birmingham, UK

17. Department of Paediatric Gastroenterology, AG&M Research Institute, Amsterdam UMC, VU University Amsterdam, Amsterdam, The Netherlands

Funder

Advanced Clinician Scientist

takeda

DR Vaillantfonds

Publisher

Informa UK Limited

Subject

Infectious Diseases,Microbiology (medical),Gastroenterology,Microbiology

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