Design, synthesis, and antifungal evaluation of novel 1,4-disubstituted 1,2,3-triazoles containing indole framework
Author:
Xu Guiqing1, Mao Shen1, Mao Longfei1, Jiang Yuqin1, Zhang Peng1, Li Wei1
Affiliation:
1. Henan Engineering Research Center of Chiral Hydroxyl Pharmaceutical, Henan Engineering Laboratory of Chemical Pharmaceuticals & Biomedical Materials, Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, P.R. China
Abstract
Abstract
In order to find novel bioactive compounds with significant antifungal activities, a series of novel 1,4-disubstituted 1,2,3-triazoles containing an indole ring via CuCl2/Zn-catalyzed Huisgen cycloaddition were designed, synthesized, and characterized. Antifungal activity against colletotrichum capsici and cotton physalospora pathogens of all the prepared compounds was evaluated, and the test results indicated that these compounds, especially 4g and 4h, showed significant inhibitory effects for fungi. All the synthesized compounds have been characterized by IR, NMR, and high-resolution mass spectra experiments. The preliminary structure activity relationship is also discussed in this paper.
Funder
Foundation of Henan Educational Committee
Publisher
Walter de Gruyter GmbH
Subject
General Chemistry
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