Design, Synthesis and Antibacterial Evaluation of Novel 1,2,3-Triazole Derivatives Incorporating 3′-Deoxythymidine-Reference-Cited by-同舟云学术

Design, Synthesis and Antibacterial Evaluation of Novel 1,2,3-Triazole Derivatives Incorporating 3′-Deoxythymidine

Published:2017-11 Issue:11 Volume:41 Page:645-649
ISSN:1747-5198
Container-title:Journal of Chemical Research
language:en
Short-container-title:Journal of Chemical Research

Author:

Mao Long-Fei¹,Xu Gui-Qing¹,Sun Bin²,Jiang Yu-Qin¹,Dong Wen-Pei¹,Zhang Shu-Ting¹,Shen Jia-Xuan¹,He Xing³

Affiliation:

1. School of Chemistry and Chemical Engineering, Henan Normal University, Henan Engineering Research Center of Chiral Hydroxyl Pharmaceutical, Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Xinxiang 453007, P.R. China

2. College of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University, Jinan 250014, P.R. China

3. College of Chemistry, Nankai University, Tianjin 300071, P.R. China

Abstract

A series of novel 1,2,3-triazole derivatives incorporating 3′-deoxythymidine were designed, synthesised and characterised. Antibacterial activity against Escherichia coli and Staphylococcus aureus was evaluated for all of the synthesised compounds and compared against standard antibiotic drugs, streptomycin sulfate and doxycycline, as controls. Some compounds showed potential antibacterial activity towards E. coli, and the best minimum inhibitory concentration was 0.14 mM. Preliminary structure-activity relationships and computational simulations were also studied.

Publisher

SAGE Publications

Subject

General Chemistry

Link

http://journals.sagepub.com/doi/pdf/10.3184/174751917X15094552081189

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