Anti-Platelet Fraction Isolated from Galega Officinalis-Reference-Cited by-同舟云学术

Anti-Platelet Fraction Isolated from Galega Officinalis

Published:2016-10-01 Issue:2 Volume:43 Page:5-10
ISSN:0324-1750
Container-title:Acta Medica Bulgarica
language:en
Short-container-title:

Author:

Atanasov A.¹

Affiliation:

1. Department of Physics and Biophysics, Faculty of Medicine, Thracian University, Armeiska Str. 11 Bg − 6000 Stara Zagora, Bulgaria

Abstract

Summary A fraction from crude extract of Galega officinalis has been purified by column chromatography on Sephadex G-25, Sepharose 4B, DEAE-Cellulose and Sephadex G-100. The final purification factor of the fraction is 120. The peak in elution profile after Sephadex G-150 shows a molecular weight of 100-140 kDa. The isolated fraction appears to have 74% polysaccharides and 23% of proteins. No loss of activity of the final fraction is observed after storage for several months at 4°C and in lyophilized condition. The fraction compounds inhibit platelet aggregation induced by ADP, collagen and thrombin.

Publisher

Walter de Gruyter GmbH

Subject

General Medicine

Reference14 articles.

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2. 2. Atanasov A.T., Radev S., Some physico-chemical characteristics, amino acids and polysaccharides content of a fraction with anti-platelet activity isolated from Galega officnalis L. 7th Bulgarian Peptide Symposium, 2016, 10-12 June, Blagoevgrad, Bulgaria.

3. 3. Hoppe H.A., Drogenkunde., 8 edn.,Walter de Gruyter, Berlin, 1975, 1, 1311.

4. 4. Atanasov A.T., Effect of the water extract of Galega officnalis L. on human platelet aggregation in vitro. Phytotherapy Research, 1994, 8, 314-316.

5. 5. Atanasov A.T., An effect of Galega officnalis L extract on platelet aggregation in rat. Journal of Herbs, Spices & Medicinal Plants, 1996, 3, 71-76.

Cited by 2 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

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2. Anti-Platelet Fraction Isolated from Galega Officinalis;Acta Medica Bulgarica;2016-10-01