Potent Antioxidant and Lipoxygenase Inhibitory Flavanone and Chalcone from Erythrina mildbraedii Harms (Fabaceae) of Cameroon-Reference-Cited by-同舟云学术

Potent Antioxidant and Lipoxygenase Inhibitory Flavanone and Chalcone from Erythrina mildbraedii Harms (Fabaceae) of Cameroon

Published:2012-01-01 Issue:1 Volume:67 Page:98-102
ISSN:1865-7117
Container-title:Zeitschrift für Naturforschung B
language:en
Short-container-title:

Author:

Ali Muhammad Shaiq¹,Ali Muhammad Imran¹,Ahmed Ghafoor¹,Afza Nighat²,Lateef Mehreen²,Iqbal Lubna²,Waffo Alain F. K.¹³,Ahmed Zeeshan¹

Affiliation:

1. H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences (ICCBS), University of Karachi, Karachi-75270, Pakistan

2. Pharmaceutical and Research Center, Pakistan Council for Scientific & Industrial Research Laboratories Complex, Karachi, Pakistan

3. Organic Chemistry Department, University of Douala, Douala, Cameroon

Abstract

In continuation of our search for new secondary metabolites from African Erythrina species, E. mildbraedii of Cameroon was investigated. As a result of this study, a new flavanone (mildbone, 1) and a new chalcone (mildbenone, 2) have been obtained and characterized by spectroscopic means. Both the compounds exhibited significant antioxidant and moderate lipoxygenase inhibitory activities. Compounds 1 and 2 showed potent antioxidant activity even stronger than the positive control. Among both the compounds, mildbone (1) was found to be potent in both the assays.

Publisher

Walter de Gruyter GmbH

Subject

General Chemistry

Link

https://www.degruyter.com/document/doi/10.1515/znb-2012-0116/pdf

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