A novel norneolignan glycoside and four new phenolic glycosides from the stems of Viburnum fordiae Hance

Abstract

Abstract A novel norneolignan glycoside (1), categorized as an unusual 7-noraryl-4′,7-epoxy-8,5′-neolignan glycoside, four new phenolic glycosides (2–5), and a known neolignan glycoside (6) have been isolated from the ethanolic extract of the stems of Viburnum fordiae Hance. Dried stems of V. fordiae were extracted with 95% ethanol, and the concentrated extract was portioned successively with petroleum ether, ethyl acetate and n-butanol. The n-butanol portion was subjected to the macroporous resin HPD-100, silica gel, octadecyl SiO2, MCI gel and Sephadex LH-20 columns to obtain six compounds. Their structures including absolute configurations were determined by spectroscopic data [1H and 13C nuclear magnetic resonance (NMR), total correlation spectroscopy (TOCSY), heteronuclear single quantum coherence (HSQC), heteronuclear multiple-bond correlation (HMBC) and optical rotatory dispersion (ORD)] and chemical methods.