An efficient synthesis of 5-halo-6-trifluoromethylpyridine-3-carbonitriles and carboxylic acids-Reference-Cited by-同舟云学术

An efficient synthesis of 5-halo-6-trifluoromethylpyridine-3-carbonitriles and carboxylic acids

Published:2017-12-20 Issue:6 Volume:23 Page:
ISSN:2191-0197
Container-title:Heterocyclic Communications
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Author:

Channapur Manjunath B.,Hall Roger G.,Lal Mukul,Pal Sitaram,Shyadligeri Ashok S.

Abstract

AbstractTrifluoromethyl containing heterocycles are an integral part of many biologically active compounds in the agro and pharmaceutical chemistry. Herein, we report an efficient and concise three-step synthesis of 5-halo-6-trifluoromethylpyridine-3-carbonitriles from a trifluoroacetyl vinylogous enamine starting material. Hydrolysis furnishes the carboxylic acids.

Publisher

Walter de Gruyter GmbH

Subject

Organic Chemistry

Link

https://www.degruyter.com/document/doi/10.1515/hc-2017-0199/pdf

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