Abstract
Abstract1,8-Naphthyridine derivatives are important heterocyclic compounds. A facile and efficient one-pot procedure for the synthesis of 5-(6-hydroxy-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-5,12-dihydrobenzo[b]pyrimido[5,4-g][1,8]naphthyridine-2,4 (1H,3H)-dione (3) via a three-component reaction of barbituric acid, 2-chloro-3-formylquinoline and ammonia under basic conditions is described.
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