Design, synthesis, and antibacterial activity of novel 8-methoxyquinoline-2-carboxamide compounds containing 1,3,4-thiadiazole moiety-Reference-Cited by-同舟云学术

Design, synthesis, and antibacterial activity of novel 8-methoxyquinoline-2-carboxamide compounds containing 1,3,4-thiadiazole moiety

Published:2017-07-28 Issue:3-4 Volume:73 Page:117-122
ISSN:1865-7125
Container-title:Zeitschrift für Naturforschung C
language:en
Short-container-title:

Author:

Qu Tengfei¹,Qu Lailiang²,Wang Xiaoguang²,Xu Ting²,Xiao Xiao³,Ding Min²,Deng Li²,Guo Yong⁴

Affiliation:

1. Key Laboratory at University of Education Department of Xinjiang Uygur Autonomous Region , Yili Normal University , Yining 835000 , P.R. China

2. School of Pharmaceutical Sciences , Zhengzhou University , Zhengzhou 450001, Henan Province , P.R. China

3. Xingping Food and Drug Administration , Xingping 713100, Shaanxi Province , P.R. China

4. School of Pharmaceutical Sciences , Zhengzhou University , Zhengzhou 450001, Henan Province , P.R. China , Phone/Fax: +86 371 67781912

Abstract

Abstract A series of novel 8-methoxyquinoline-2-carboxamide compounds containing 1,3,4-thiadiazole moiety was designed and synthesized by using an active substructure combination method. Then, the antibacterial activities of all the target compounds were evaluated in vitro against three Gram-positive bacteria and three Gram-negative bacteria. The antibacterial assay showed that some target compounds displayed moderate to good antibacterial efficacy in comparison with the reference drug Chloromycin. Some interesting results of structure-activity relationships were also discussed.

Publisher

Walter de Gruyter GmbH

Subject

General Biochemistry, Genetics and Molecular Biology

Link

https://www.degruyter.com/document/doi/10.1515/znc-2017-0063/pdf

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