Antibacterial and synergistic activity of a new 8-hydroxyquinoline derivative against methicillin-resistant <i>Staphylococcus aureus</i>-Reference-Cited by-同舟云学术

Antibacterial and synergistic activity of a new 8-hydroxyquinoline derivative against methicillin-resistant Staphylococcus aureus

Published:2022-04 Issue:6 Volume:17 Page:425-436
ISSN:1746-0913
Container-title:Future Microbiology
language:en
Short-container-title:Future Microbiology

Author:

Joaquim Angélica R¹^ORCID,Boff Roberta T²,Adam Franciele C²,Lima-Morales Daiana³,Cesare Maycon A¹,Kaminski Taís FA¹,Teixeira Mário L⁴,Fuentefria Alexandre M¹²,Andrade Saulo F¹²,Martins Andreza F¹²³^ORCID

Affiliation:

1. Programa de Pós-graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Porto Alegre, 90610-000, Brazil

2. Programa de Pós-graduação em Microbiologia Agrícola e do Ambiente, Universidade Federal do Rio Grande do Sul, Porto Alegre, 90050-170, Brazil

3. Laboratório de Pesquisa em Resistência Bacteriana, Hospital de Clínicas de Porto Alegre, Rio Grande do Sul, Porto Alegre, 90035-903, Brazil

4. Laboratório de Farmacologia, Instituto Federal Catarinense, Campus Concórdia, Concórdia, 89703-720, Brazil

Abstract

Aim: To evaluate the antibacterial and synergistic effect of a new 8-hydroxyquinoline derivative (PH176) against MRSA. Materials & methods: PH176 activity was determined by broth microdilution against 38 Staphylococcus aureus clinical isolates. The antibacterial and synergistic effects with oxacillin and nitroxoline were evaluated by time–kill assays to five MRSA isolates. Toxicity was evaluated by in vitro and ex vivo models. Results: The MIC50 and MIC90 of PH176 were 16 and 32 μg/ml, respectively. The PH176 and nitroxoline led to a reduction in colony count for four isolates and the combination of PH176 and oxacillin acted synergically for three isolates. Furthermore, PH176 was determined to be noncytotoxic/nonirritant. Conclusion: These results demonstrate that PH176 has revealed promising results to be a potential candidate to treat MRSA infections.

Funder

Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – Brasil (CAPES) – Finance Code 001

Publisher

Future Medicine Ltd

Subject

Microbiology (medical),Microbiology

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fmb-2021-0198

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