Two new usnic acid derivatives from the endophytic fungus Mycosphaerella sp.-Reference-Cited by-同舟云学术

Two new usnic acid derivatives from the endophytic fungus Mycosphaerella sp.

Published:2018-09-04 Issue:11-12 Volume:73 Page:449-455
ISSN:1865-7125
Container-title:Zeitschrift für Naturforschung C
language:en
Short-container-title:

Author:

de Oliveira Djalma M.¹,Pereira Cristiane B.²,Mendes Graziele²,Junker Jochen³,Kolloff Markus⁴,Rosa Luiz H.²,Rosa Carlos A.²,Alves Tânia M.A.⁴,Zani Carlos L.⁴,Johann Susana²,Cota Betania B.⁵^ORCID

Affiliation:

1. Department of Sciences and Technologies , State University of Bahia Southwest , Jequié, Bahia , Brazil

2. Department of Microbiology , Institute of Biological Sciences, Federal University of Minas Gerais , Belo Horizonte, Minas Gerais , Brazil

3. Center for Technological Development in Health, Oswaldo Cruz Fundation , Rio de Janeiro , Brazil

4. Laboratory of Chemistry of Natural Bioactive Products, René Rachou Institute, Oswaldo Cruz Foundation , Belo Horizonte, Minas Gerais , Brazil

5. Laboratory of Chemistry of Natural Bioactive Products, René Rachou Institute, Oswaldo Cruz Foundation , Belo Horizonte, 30190-009 Minas Gerais , Brazil , Phone: +55 31 33497845, Fax: +55 31 32953115

Abstract

Abstract The endophytic fungus Mycosphaerella sp. (UFMGCB2032) was isolated from the healthy leaves of Eugenia bimarginata, a plant from the Brazilian savanna. Two novel usnic acid derivatives, mycousfuranine (1) and mycousnicdiol (2), were isolated from the ethyl acetate extract, and their structure was elucidated by NMR and MS analyses. Compounds 1 and 2 exhibited moderate antifungal activities against Cryptococcus neoformans and Cryptococcus gattii, each with minimum inhibitory concentration values of 50.0 μg/mL and 250.0 μg/mL, respectively.

Publisher

Walter de Gruyter GmbH

Subject

General Biochemistry, Genetics and Molecular Biology

Link

https://www.degruyter.com/document/doi/10.1515/znc-2017-0162/pdf

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