The prevalence of and risk factors for stillbirths in women with severe preeclampsia in a high-burden setting at Mpilo Central Hospital, Bulawayo, Zimbabwe
Author:
Ngwenya Solwayo123, Jones Brian4, Mwembe Desmond4, Nare Hausitoe4, Heazell Alexander E.P.45
Affiliation:
1. Mpilo Central Hospital Bulawayo , Zimbabwe 2. Royal Women’s Clinic , Bulawayo , Zimbabwe 3. National University of Science and Technology Medical Technology Medical School , Bulawayo , Zimbabwe 4. National University of Science and Technology , Bulawayo , Zimbabwe 5. Manchester Academic Health Science Centre, Faculty of Biology, Medicine and Health , The University of Manchester Manchester , UK
Abstract
Abstract
Objectives
Stillbirth remains a global public health issue; in low-resource settings stillbirth rates remain high (>12 per 1,000 births target of Every Newborn Action Plan). Preeclampsia is major risk factor for stillbirths. This study aimed to determine the prevalence and risk factors for stillbirth amongst women with severe preeclampsia at Mpilo Central Hospital.
Methods
A retrospective cross-sectional study was conducted of women with severe preeclampsia from 01/01/2016 to 31/12/2018 at Mpilo Central Hospital, Bulawayo, Zimbabwe. Multivariable logistic regression was used to determine risk factors that were independently associated with stillbirths.
Results
Of 469 women that met the inclusion criteria, 46 had a stillbirth giving a stillbirth prevalence of 9.8%. The risk factors for stillbirths in women with severe preeclampsia were: unbooked status (adjusted odds ratio (aOR) 3.01, 95% (confidence interval) CI 2.20–9.10), frontal headaches (aOR 2.33, 95% CI 0.14–5.78), vaginal bleeding with abdominal pain (aOR 4.71, 95% CI 1.12–19.94), diastolic blood pressure ≥150 mmHg (aOR 15.04, 95% CI 1.78–126.79), platelet count 0–49 × 109/L (aOR 2.80, 95% CI 1.26–6.21), platelet count 50–99 × 109/L (aOR 2.48, 95% CI 0.99–6.18), antepartum haemorrhage (aOR 12.71, 95% CI 4.15–38.96), haemolysis elevated liver enzymes syndrome (HELLP) (aOR 6.02, 95% CI 2.22–16.33) and fetal sex (aOR 2.75, 95% CI 1.37–5.53).
Conclusions
Women with severe preeclampsia are at significantly increased risk of stillbirth. This study has identified risk factors for stillbirth in this high-risk population; which we hope could be used by clinicians to reduce the burden of stillbirths in women with severe preeclampsia.
Publisher
Walter de Gruyter GmbH
Subject
Obstetrics and Gynecology,Pediatrics, Perinatology and Child Health
Reference30 articles.
1. Lawn, JE, Blencowe, H, Waiswa, P, Amouzou, A, Mathers, C, Hogan, D, et al.. Lancet ending preventable stillbirths series study group; lancet stillbirth epidemiology investigator group stillbirths: rates, risk factors, and acceleration towards 2030. Lancet 2016;387:587–603. 2. de Bernis, L, Kinney, MV, Stones, W, Hoope-Bender, PT, Vivio, D, Leisher, SH. Lancet ending preventable stillbirths series study group; lancet ending preventable stillbirths series advisory group stillbirths: ending preventable deaths by 2030. Lancet 2016;387:703–16. 3. Lawn, JE, Blencowe, H, Waiswa, P, Amouzou, A, Mathers, C, Hogan, D, et al.. Stillbirths: rates, risk factors, and acceleration towards 2030. Lancet 2016;387:587–603. 4. Heazell, EP, Siassakos, D, Blencowe, H, Burden, C, Bhutta, ZA, Cacciatore, J, et al.. Lancet ending preventable stillbirths series study group; lancet ending preventable stillbirths investigator group stillbirths: economic and psychosocial consequences. Lancet 2016;387:604–16. 5. Angell, JN, Abdul-Mumin, AS, Katherine, J, Gold, KJ. Determining the cause of stillbirth in Kumasi, Ghana. Int J Gynaecol Obstet 2019;147:173–8. https://doi.org/10.1002/ijgo.12930.
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