Vertical transmission of SARS-CoV-2 – data from the German COVID-19 related obstetric and neonatal outcome study (CRONOS)
Author:
Mand Nadine1ORCID, Rüdiger Mario2, Hütten Matthias3, Maier Rolf Felix1, Mense Lars2, Pecks Ulrich4
Affiliation:
1. Department of Pediatrics , Philipps University of Marburg , Marburg , Germany 2. Department of Pediatrics , University of Dresden , Dresden , Germany 3. Department of Pediatrics , University of Maastricht , Maastricht , Netherlands 4. Department of Obstetrics , Christian-Albrechts-University of Kiel , Kiel , Germany
Abstract
Abstract
Objectives
We aimed to determine the frequency of SARS-CoV-2 positivity in newborns born to mothers with peripartum SARS-CoV-2 infection in a German cohort, to identify potential risk factors associated with neonatal SARS-CoV-2 infection, and to present short-term outcomes of newborns with vertical transmission of SARS-CoV-2.
Methods
Data on women with SARS-CoV-2 infection occurring anytime during their pregnancy was gathered prospectively within the CRONOS registry. From April 2020 to February 2023 a total of 8,540 women had been registered. The timing and the probability of mother-to-child transmission in neonates born to women with perinatal SARS-CoV-2 infection were classified using the WHO classification system. The severity of maternal infection, maternal vaccination status, type of dominant virus, and perinatal outcome parameters were analyzed as potential risk factors for neonatal SARS-CoV-2 infection.
Results
6.3 % resp. 42.9 % of tested newborns and stillbirths were SARS-CoV-2 positive. 2.1 % of newborns with confirmed and possible SARS-CoV-2 infection were identified. Severe maternal COVID-19 (odds ratio 4.4, 95 % confidence interval 1.8–11.1) and maternal infection with the Delta virus (OR 3.2, 1.4–7.7) were associated with neonatal SARS-CoV-2 infection. Newborns with a confirmed or possible infection were significantly more often admitted to the NICU (65.2 % neonatal infection vs. 27.5 % non, p<0.001).
Conclusions
The rate of neonatal SARS-CoV-2 positivity was higher in our cohort than previously reported, neonatal SARS-CoV-2 infections were rare. Our data emphasizes confirmative testing should be performed in newborns of SARS-CoV-2 infected mothers to identify neonatal SARS-CoV-2 infection as an underlying pathology leading to NICU admission.
Funder
CAU/UKSH, Land Schleswig-Holstein Krumme-Stiftung Kiel DGPM
Publisher
Walter de Gruyter GmbH
Reference37 articles.
1. Moza, A, Duica, F, Antoniadis, P, Bernad, ES, Lungeanu, D, Craina, M, et al.. Outcome of newborns with confirmed or possible SARS-CoV-2 vertical infection-A Scoping review. Diagnostics 2023;13:245. https://doi.org/10.3390/diagnostics13020245. 2. Allotey, J, Chatterjee, S, Kew, T, Gaetano, A, Stallings, E, Fernández-García, S, et al.. SARS-CoV-2 positivity in offspring and timing of mother-to-child transmission: living systematic review and meta-analysis. BMJ 2022;376:e067696. https://doi.org/10.1136/bmj-2021-067696. 3. Mand, N, Iannaccone, A, Longardt, AC, Hutten, M, Mense, L, Oppelt, P, et al.. Neonatal outcome following maternal infection with SARS-CoV-2 in Germany: COVID-19-related obstetric and neonatal outcome study (CRONOS). Arch Dis Child Fetal Neonatal Ed 2021;107:454–6. https://doi.org/10.1136/archdischild-2021-322100. 4. Flaherman, VJ, Afshar, Y, Boscardin, WJ, Keller, RL, Mardy, AH, Prahl, MK, et al.. Infant outcomes following maternal infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): first report from the pregnancy Coronavirus outcomes registry (PRIORITY) study. Clin Infect Dis 2020;73:e2810-13. https://doi.org/10.1093/cid/ciaa1411. 5. Knight, M, Bunch, K, Vousden, N, Morris, E, Simpson, N, Gale, C, et al.. Characteristics and outcomes of pregnant women admitted to hospital with confirmed SARS-CoV-2 infection in UK: national population based cohort study. Br Med J 2020;369:m2107. https://doi.org/10.1136/bmj.m2107.
Cited by
3 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
|
|