Age-related changes in peripheral T-cell subpopulations in elderly individuals: An observational study

Author:

Quan Xiao-Qing1,Ruan Lei2,Zhou Hai-Rong1,Gao Wei-Liang1,Zhang Qing3,Zhang Cun-Tai2

Affiliation:

1. Department of Geriatrics, Department of General Practice, Shenzhen Longhua District Central Hospital, The Affiliated Central Hospital of Shenzhen Longhua District, Guangdong Medical University , Shenzhen , 518000 , China

2. Department of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan , 430030 , China

3. Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan , 430030 , China

Abstract

Abstract The age-related decline in T-cell function among elderly individuals remains unclear. We thus investigated the interrelationship between T-cell subsets and age to identify the changes in T-cell phenotypes and develop an age prediction model for the elderly population. A total of 127 individuals aged >60 years were divided into three groups (youngest-old group, 61–70 years, n = 34; middle-old group, 71–80 years, n = 53; and oldest-old group, ≥ 81 years, n = 40). The percentage of CD8+CD28− cells (P = 0.001) was highest in the oldest-old group and then followed by the middle-old group, while the youngest-old group was the lowest. Both females and males demonstrated significant decreases in the absolute counts of CD4+CD45RA+ cells (P = 0.020; P = 0.002) and CD8+CD28+ cells (P = 0.015; P = 0.005) with age. Multivariate linear regression showed that the percentage of CD8+CD28− cells (P < 0.001) was an independent predictor of aging after adjusting for sex, body mass index, hospitalization duration, smoking, drinking, chronic medical illness, and medications at admission. In conclusion, our results suggest that aging in elderly individuals is accompanied by a decrease in the counts of T-cell subpopulations. CD8+CD28− cells may be potential targets for elderly individuals in antiaging-related immunosenescence.

Publisher

Walter de Gruyter GmbH

Subject

General Agricultural and Biological Sciences,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Neuroscience

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