Differential cytotoxic activity of the petroleum ether extract and its furanosesquiterpenoid constituents from Commiphora molmol resin-Reference-Cited by-同舟云学术

Differential cytotoxic activity of the petroleum ether extract and its furanosesquiterpenoid constituents from Commiphora molmol resin

Published:2015-03-01 Issue:3-4 Volume:70 Page:87-92
ISSN:1865-7125
Container-title:Zeitschrift für Naturforschung C
language:en
Short-container-title:

Author:

Ayyad Seif-Eldin N.,Hoye Thomas R.¹,Alarif Walied M.²,Al Ahmadi Sana’a M.³,Basaif Salim A.⁴,Ghandourah Mohamed A.²,Badria Farid A.⁵

Affiliation:

1. Departments of Chemistry and Medicinal Chemistry, University of Minnesota, Minneapolis, MN 55455, USA

2. Faculty of Marine Sciences, Department of Marine Chemistry, King Abdulaziz University, P.O. 80207, Jeddah 21589, KSA

3. Faculty of Science, Chemistry Department, Taibah University, Al-Madinah Al-Munawarah, P.O. 30100, KSA

4. Faculty of Science, Department of Chemistry, King Abdulaziz University, P.O. 80203, Jeddah 21589, KSA

5. Faculty of Pharmacy, Pharmacognosy Department, Mansoura University, Mansoura 35516, Egypt

Abstract

Abstract This study revealed a differential cytotoxic activity of the petroleum ether extract (IC50=5 μg/mL) of the resinous exudates of Commiphora molmol against two mouse cell lines KA31T and NIH3T3 (untransformed and transformed mouse fibroblasts, respectively). Four new compounds (1–4) and five known compounds (5–9) were isolated from the petroleum ether extract. The identity of these new compounds was determined as γ-elemane lactone (1), 5-αH,8-βH-eudesma-1,3,7(11)-trien-8,12-olide (2), 2-hydroxy-11,12-dihydrofuranodiene (3), and 2-hydroxyfuranodiene (4). 1 and 2 displayed the highest cytotoxic activity against NIH3T3 cells. 7 and 9 exhibited moderate cytotoxic activity against KA31T cells. Compounds 3–6 showed weak cytotoxic activities against both cell lines. These results may explain the high efficacy of the petroleum ether fraction in several myrrh-derived pharmaceutical preparations.

Publisher

Walter de Gruyter GmbH

Subject

General Biochemistry, Genetics and Molecular Biology

Link

https://www.degruyter.com/document/doi/10.1515/znc-2014-4191/pdf

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