PTEN protein expression has role in predicting disease-free-interval in endometrioid endometrial carcinoma
Author:
Shafiee Mohamad Nasir1ORCID, Lim Wei Keith2, Poh Shwen Shi Cheryl2, Mohamed Yasin Ira Adila2, Azemi Aina Fatini2, Zakaria Muhammad Luqman2, Hannaan Abdul Hafizz Abdul Muzhill13, Mustangin Muaatamarulain3, Chandralega Kampan Nirmala1, Abd Aziz Nor Haslinda1, Md Zain Reena Rahayu3
Affiliation:
1. Department of Obstetrics and Gynaecology, Faculty of Medicine , Universiti Kebangsaan Malaysia Medical Centre , Cheras , Kuala Lumpur , Malaysia 2. Special Study Module, Undergraduate Program, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre , Cheras , Kuala Lumpur , Malaysia 3. Department of Pathology , Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre , Cheras , Kuala Lumpur , Malaysia
Abstract
Abstract
Objectives
To determine the significance of tumour PTEN protein expression in endometrioid endometrial carcinoma (EEC) and it is correlation with tumour characteristics.
Methods
A total of 30 eligible archived paraffin-embedded tissue blocks from 61 EEC cases (January 2015–December 2017) were retrieved from the Histopathology Laboratory in Universiti Kebangsaan Malaysia Medical Centre (UKMMC) following institutional ethic approval. For PTEN protein detection, immunohistochemistry (IHC) staining was performed and the data was correlated with clinicopathologic parameters.
Results
Fourteen samples (46.7%) showed positive PTEN protein expression, while 16 (53.3%) were negative. The mean age was 62.00 ± 9.51 years old, while the mean Body Mass Index (BMI) was 27.28 ± 7.16 kg/m2. There was no significant difference between age (p=0.27, 95% CI: −10.98 to 3.21) and BMI (p=0.67, 95% CI: −4.30 to 6.58) with PTEN protein expression. There were significant correlation between PTEN protein expression with myometrial invasion (p=0.010), but not with lymphovascular space invasion (p=0.743), grade (p=0.532), stage (p=0.733) and CA-125 level (p=0.47). The higher stage correlates with the presence of LVSI (p=0.002). PTEN positive associated with longer disease-free-interval (p=0.025), but not improving the overall survival (p=0.38)
Conclusions
Positive PTEN protein expression correlates with less myometrial invasion.
Publisher
Walter de Gruyter GmbH
Subject
Endocrinology,Molecular Biology,General Medicine,Endocrinology, Diabetes and Metabolism
Reference32 articles.
1. Wan-Nor-Asyikeen, WA, Jalil, NAC, Zain, AAM, Siti-Azrin, A, Che Jalil, N, Othman, N, et al.. Endometrial cancer in hospital Universiti Sains Malaysia. Asian Pac J Cancer Prev APJCP 2016;17:2867–70. 2. Zainal Ariffin, O, Nor Saleha, I. National cancer registry report 2007. Malaysia: Ministry of Health; 2011. 3. Setiawan, VW, Yang, HP, Pike, MC, McCann, SE, Yu, H, Xiang, Y-B, et al.. Type I and II endometrial cancers: have they different risk factors? J Clin Oncol 2013;31:2607. https://doi.org/10.1200/jco.2012.48.2596. 4. Lax, SF. Molecular genetic pathways in various types of endometrial carcinoma: from a phenotypical to a molecular-based classification. Virchows Arch 2004;444:213–23. https://doi.org/10.1007/s00428-003-0947-3. 5. Rewcastle, E, Varhaugvik, AE, Gudlaugsson, E, Steinbakk, A, Skaland, I, van Diermen, B, et al.. Assessing the prognostic value of PAX2 and PTEN in endometrial carcinogenesis. Endocr Relat Canc 2018;25:981–91. https://doi.org/10.1530/erc-18-0106.
|
|