Type I and II Endometrial Cancers: Have They Different Risk Factors?
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Published:2013-07-10
Issue:20
Volume:31
Page:2607-2618
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ISSN:0732-183X
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Container-title:Journal of Clinical Oncology
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language:en
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Short-container-title:JCO
Author:
Setiawan Veronica Wendy1, Yang Hannah P.1, Pike Malcolm C.1, McCann Susan E.1, Yu Herbert1, Xiang Yong-Bing1, Wolk Alicja1, Wentzensen Nicolas1, Weiss Noel S.1, Webb Penelope M.1, van den Brandt Piet A.1, van de Vijver Koen1, Thompson Pamela J.1, Strom Brian L.1, Spurdle Amanda B.1, Soslow Robert A.1, Shu Xiao-ou1, Schairer Catherine1, Sacerdote Carlotta1, Rohan Thomas E.1, Robien Kim1, Risch Harvey A.1, Ricceri Fulvio1, Rebbeck Timothy R.1, Rastogi Radhai1, Prescott Jennifer1, Polidoro Silvia1, Park Yikyung1, Olson Sara H.1, Moysich Kirsten B.1, Miller Anthony B.1, McCullough Marjorie L.1, Matsuno Rayna K.1, Magliocco Anthony M.1, Lurie Galina1, Lu Lingeng1, Lissowska Jolanta1, Liang Xiaolin1, Lacey James V.1, Kolonel Laurence N.1, Henderson Brian E.1, Hankinson Susan E.1, Håkansson Niclas1, Goodman Marc T.1, Gaudet Mia M.1, Garcia-Closas Montserrat1, Friedenreich Christine M.1, Freudenheim Jo L.1, Doherty Jennifer1, De Vivo Immaculata1, Courneya Kerry S.1, Cook Linda S.1, Chen Chu1, Cerhan James R.1, Cai Hui1, Brinton Louise A.1, Bernstein Leslie1, Anderson Kristin E.1, Anton-Culver Hoda1, Schouten Leo J.1, Horn-Ross Pamela L.1,
Affiliation:
1. Veronica Wendy Setiawan, Malcolm C. Pike, and Brian E. Henderson, University of Southern California, Los Angeles; James V. Lacey, Jr, and Leslie Bernstein, Beckman Research Institute, City of Hope, Duarte; Hoda Anton-Culver, University of California, Irvine; Pamela L. Horn-Ross, Cancer Prevention Institute of California, Fremont, CA; Hannah P. Yang, Nicolas Wentzensen, Catherine Schairer, Yikyung Park, and Louise A. Brinton, National Cancer Institute, Bethesda, MD; Malcolm C. Pike, Robert A. Soslow,...
Abstract
Purpose Endometrial cancers have long been divided into estrogen-dependent type I and the less common clinically aggressive estrogen-independent type II. Little is known about risk factors for type II tumors because most studies lack sufficient cases to study these much less common tumors separately. We examined whether so-called classical endometrial cancer risk factors also influence the risk of type II tumors. Patients and Methods Individual-level data from 10 cohort and 14 case-control studies from the Epidemiology of Endometrial Cancer Consortium were pooled. A total of 14,069 endometrial cancer cases and 35,312 controls were included. We classified endometrioid (n = 7,246), adenocarcinoma not otherwise specified (n = 4,830), and adenocarcinoma with squamous differentiation (n = 777) as type I tumors and serous (n = 508) and mixed cell (n = 346) as type II tumors. Results Parity, oral contraceptive use, cigarette smoking, age at menarche, and diabetes were associated with type I and type II tumors to similar extents. Body mass index, however, had a greater effect on type I tumors than on type II tumors: odds ratio (OR) per 2 kg/m2 increase was 1.20 (95% CI, 1.19 to 1.21) for type I and 1.12 (95% CI, 1.09 to 1.14) for type II tumors (Pheterogeneity < .0001). Risk factor patterns for high-grade endometrioid tumors and type II tumors were similar. Conclusion The results of this pooled analysis suggest that the two endometrial cancer types share many common etiologic factors. The etiology of type II tumors may, therefore, not be completely estrogen independent, as previously believed.
Publisher
American Society of Clinical Oncology (ASCO)
Subject
Cancer Research,Oncology
Cited by
631 articles.
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